A Bioprinted Bruch's Membrane for Modeling Smoke‐Induced Retinal Pigment Epithelium Degeneration via Hybrid Membrane Printing Technology
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200728
Abstract: The retinal pigment epithelium (RPE) not only forms the outer blood‐retinal barrier (oBRB) but also plays a multifunctional role in the ocular system. The loss of this epithelium leads to serious diseases resulting in vision… read more here.
Keywords: technology; pigment epithelium; retinal pigment; model ... See more keywords
Fat mass and obesity‐associated protein alleviates Aβ1–40 induced retinal pigment epithelial cells degeneration via PKA/CREB signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11959
Abstract: Amyloid‐β (Aβ) is thought to be a critical pathologic factor of retinal pigment epithelium (RPE) degeneration in age‐related macular degeneration (AMD). Aβ induces inflammatory responses in RPE cells and recent studies demonstrate the N6‐methyladenosine (m6A)… read more here.
Keywords: degeneration; pka; rpe degeneration; retinal pigment ... See more keywords
Synthesis of Unsymmetrical Squaramides as Allosteric GSK‐3β Inhibitors Promoting β‐Catenin‐Mediated Transcription of TCF/LEF in Retinal Pigment Epithelial Cells
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200456
Abstract: The glycogen synthase kinase 3β (GSK‐3β) is a ubiquitous enzyme that is a validated target for the development of potential therapeutics useful in several diseases including retinal degeneration. Aiming at developing an innovative class of… read more here.
Keywords: epithelial cells; pigment epithelial; retinal pigment; tcf lef ... See more keywords
Retinal pigment epithelium adenoma in vitreous fluid cytology
Sign Up to like & getrecommendations! Published in 2017 at "Diagnostic Cytopathology"
DOI: 10.1002/dc.23781
Abstract: Ocular cytology specimens are relatively uncommon, adding to the difficulty of their evaluation by cytopathologists. While melanomas account for a majority of primary intraocular pigmented lesions, other diagnostic considerations must be included in the differential.… read more here.
Keywords: retinal pigment; epithelium adenoma; cytology; pigment epithelium ... See more keywords
Retinal pigment epithelium expansion around the neural retina occurs in two separate phases with distinct mechanisms
Sign Up to like & getrecommendations! Published in 2017 at "Developmental Dynamics"
DOI: 10.1002/dvdy.24525
Abstract: Background: The retinal pigment epithelium (RPE) is a specialized monolayer of epithelial cells that forms a tight barrier surrounding the neural retina. RPE cells are indispensable for mature photoreceptor renewal and survival, yet how the… read more here.
Keywords: neural retina; expansion; epithelium; retinal pigment ... See more keywords
MiR‐455‐5p ameliorates HG‐induced apoptosis, oxidative stress and inflammatory via targeting SOCS3 in retinal pigment epithelial cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28755
Abstract: Diabetic retinopathy (DR) remains the leading cause of blindness in adults with diabetes mellitus. Numerous microRNAs (miRNAs) have been identified to modulate the pathogenesis of DR. The main purpose of this study was to evaluate… read more here.
Keywords: apoptosis; pigment epithelial; mir 455; stress ... See more keywords
Response of Retinal Pigment Epithelium (RPE)‐Choroid Explants to Thermal Stimulation Therapy of the RPE (TSR)
Sign Up to like & getrecommendations! Published in 2020 at "Lasers in Surgery and Medicine"
DOI: 10.1002/lsm.23288
Abstract: The thermal stimulation therapy of the retinal pigment epithelium (TSR) is a sublethal laser technique for thermal stimulation of the retinal pigment epithelium (RPE)‐Bruch's membrane (BrM)‐complex. The aim of this study was to investigate the… read more here.
Keywords: thermal stimulation; retinal pigment; pigment epithelium; rpe ... See more keywords
Nanoprotection Against Retinal Pigment Epithelium Degeneration via Ferroptosis Inhibition.
Sign Up to like & getrecommendations! Published in 2021 at "Small methods"
DOI: 10.1002/smtd.202100848
Abstract: Lethal oxidative stress and ferrous ion accumulation-mediated degeneration/death in retinal pigment epithelium (RPE) exert an indispensable impact on retinal degenerative diseases with irreversible visual impairment, especially in age-related macular degeneration (AMD), but corresponding pathogenesis-oriented medical… read more here.
Keywords: pigment epithelium; retinal pigment; degeneration; capb ... See more keywords
Disease-causing mutations associated with bestrophinopathies promote apoptosis in retinal pigment epithelium cells
Sign Up to like & getrecommendations! Published in 2020 at "Graefe's Archive for Clinical and Experimental Ophthalmology"
DOI: 10.1007/s00417-020-04636-5
Abstract: Purpose Best vitelliform macular dystrophy (BVMD) and autosomal recessive bestrophinopathy (ARB) are two kinds of bestrophinopathies which are caused by BEST1 mutations and characterized by accumulation of lipofuscin-like materials on the retinal pigment epithelium cell-photoreceptor… read more here.
Keywords: s142g a146t; apoptosis; rpe cells; pigment epithelium ... See more keywords
Bevacizumab induces oxidative cytotoxicity and apoptosis via TRPM2 channel activation in retinal pigment epithelial cells: Protective role of glutathione
Sign Up to like & getrecommendations! Published in 2021 at "Graefe's Archive for Clinical and Experimental Ophthalmology"
DOI: 10.1007/s00417-021-05074-7
Abstract: Bevacizumab (BEV) is a blocker of circulating VEGF A generation. However, BEV has adverse apoptotic and cytotoxic effects via upregulation of mitochondrial reactive oxygen species (ROS) and TRPM2 activation, and downregulation of cytosolic glutathione (GSH)… read more here.
Keywords: pigment epithelial; treatment; gsh; bev ... See more keywords
Connexin43 hemichannel block protects against retinal pigment epithelial cell barrier breakdown
Sign Up to like & getrecommendations! Published in 2019 at "Acta Diabetologica"
DOI: 10.1007/s00592-019-01352-3
Abstract: Aims The retinal pigment epithelium (RPE) is an important component of the outer blood–retinal barrier (BRB) that separates the choroid from the rest of the retina. Loss of RPE-mediated BRB integrity is a key feature… read more here.
Keywords: connexin43; retinal pigment; hemichannel block; connexin43 hemichannel ... See more keywords