Mussel-inspired injectable hydrogel and its counterpart for actuating proliferation and neuronal differentiation of retinal progenitor cells.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2018.12.015
Abstract: Biomaterials-mediated retinal progenitor cell (RPC)-based transplantation therapy has shown substantial potential for retinal degeneration (RD), but it is limited by the poor RPC survival, proliferation and differentiation. Herein, the gelatin-hyaluronic acid (Gel-HA)-based hydrogels formed via… read more here.
Keywords: retinal progenitor; mussel inspired; proliferation; differentiation ... See more keywords
A novel electro-chemotactic approach to impact the directional migration of transplantable retinal progenitor cells.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental eye research"
DOI: 10.1016/j.exer.2019.06.002
Abstract: Photoreceptor degeneration is a significant cause of visual impairment in the United States and globally. Cell replacement therapy shows great promise in restoring vision by transplanting stem-like cells into the sub-retinal space as substitutes for… read more here.
Keywords: retinal progenitor; transplantable retinal; migration; chemotactic fields ... See more keywords
Synaptic repair and vision restoration in advanced degenerating eyes by transplantation of retinal progenitor cells
Sign Up to like & getrecommendations! Published in 2021 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2021.06.002
Abstract: Summary Stem cell transplantation shows enormous potential for treatment of incurable retinal degeneration (RD). To determine if and how grafts connect with the neural circuits of the advanced degenerative retina (ADR) and improve vision, we… read more here.
Keywords: synaptic repair; progenitor cells; retinal progenitor; transplantation ... See more keywords
Polycomb repression complex 2 is required for the maintenance of retinal progenitor cells and balanced retinal differentiation.
Sign Up to like & getrecommendations! Published in 2018 at "Developmental biology"
DOI: 10.1016/j.ydbio.2017.11.004
Abstract: Polycomb repressive complexes maintain transcriptional repression of genes encoding crucial developmental regulators through chromatin modification. Here we investigated the role of Polycomb repressive complex 2 (PRC2) in retinal development by inactivating its key components Eed… read more here.
Keywords: retinal differentiation; polycomb; progenitor cells; retinal progenitor ... See more keywords
Prpf31 is essential for the survival and differentiation of retinal progenitor cells by modulating alternative splicing
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab003
Abstract: Abstract Dysfunction of splicing factors often result in abnormal cell differentiation and apoptosis, especially in neural tissues. Mutations in pre-mRNAs processing factor 31 (PRPF31) cause autosomal dominant retinitis pigmentosa, a progressive retinal degeneration disease. The… read more here.
Keywords: progenitor cells; retinal progenitor; differentiation; survival differentiation ... See more keywords
Absence of Connexin 43 results in smaller retinas and arrested, depolarized retinal progenitor cells in human retinal organoids.
Sign Up to like & getrecommendations! Published in 2022 at "Stem cells"
DOI: 10.1093/stmcls/sxac017
Abstract: The development of the vertebrate retina relies on complex regulatory mechanisms to achieve its characteristic layered morphology containing multiple neuronal cell types. While connexin 43 (CX43) is not expressed by mature retinal neurons mutations in… read more here.
Keywords: absence connexin; gja1; retinal organoids; retinal progenitor ... See more keywords
Betacellulin regulates the proliferation and differentiation of retinal progenitor cells in vitro
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13321
Abstract: Retinal progenitor cells (RPCs) hold great potential for the treatment of retinal degenerative diseases. However, their proliferation capacity and differentiation potential towards specific retinal neurons are limited, which limit their future clinical applications. Thus, it… read more here.
Keywords: retinal progenitor; differentiation; rpcs; proliferation differentiation ... See more keywords
In vivo study to assess dosage of allogeneic pig retinal progenitor cells: Long‐term survival, engraftment, differentiation and safety
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17332
Abstract: Despite notable efforts and significant therapeutical advances, age‐related macular degeneration remains the single most common reason for vision loss. Retinal progenitor cells (RPCs) are considered promising candidates for cellular treatments that repair and restore vision.… read more here.
Keywords: long term; pig retinal; progenitor cells; retinal progenitor ... See more keywords
miR-381-3p Cooperated With Hes1 to Regulate the Proliferation and Differentiation of Retinal Progenitor Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.853215
Abstract: Retinal progenitor cells (RPCs) transplantation has become a promising therapy for retinal degeneration, which is a major kind of ocular diseases causing blindness. Since RPCs have limited proliferation and differentiation abilities toward retinal neurons, it… read more here.
Keywords: proliferation; hes1; mir 381; retinal progenitor ... See more keywords