Vision-Targeted Health-Related Quality of Life in Adult Survivors of Retinoblastoma
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Ophthalmology"
DOI: 10.1001/jamaophthalmol.2018.1082
Abstract: Importance Retinoblastoma survivors are at risk for adverse oculo-visual outcomes. Limited data are available regarding long-term vision-targeted health-related quality of life (HRQoL) of adult retinoblastoma survivors. Objective To examine vision-targeted HRQoL as reported on the… read more here.
Keywords: adult; retinoblastoma; retinoblastoma survivors; quality life ... See more keywords
PRC1 gene silencing inhibits proliferation, invasion, and angiogenesis of retinoblastoma cells through the inhibition of the Wnt/β‐catenin signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28942
Abstract: Retinoblastoma is an ocular malignancy occurring in childhood. The current study evaluates the ability of silenced PRC1 on retinoblastoma cell proliferation, and angiogenesis via the Wnt/β‐catenin signaling pathway. A total of 36 cases of retinoblastoma… read more here.
Keywords: retinoblastoma cells; angiogenesis; catenin; proliferation ... See more keywords
Danish heritable retinoblastoma survivors' perspectives on reproductive choices: “It's important for me, not to pass on this condition”
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Genetic Counseling"
DOI: 10.1002/jgc4.1618
Abstract: Despite reporting an overall normal life, survivors of heritable retinoblastoma face numerous physical and psychosocial issues. In particular, reproductive decision‐making is often complex and difficult. This study aims to examine survivors' reflections on passing on… read more here.
Keywords: danish heritable; retinoblastoma; condition; retinoblastoma survivors ... See more keywords
Prenatal ultrasonographic detection and prenatal (prior to birth) management of hereditary retinoblastoma
Sign Up to like & getrecommendations! Published in 2017 at "Graefe's Archive for Clinical and Experimental Ophthalmology"
DOI: 10.1007/s00417-017-3841-4
Abstract: Dear Editor, Retinoblastoma is a life-threatening intraocular malignancy that manifests, on average, by 15 months after birth and can lead to blindness, loss of eye, or death [1, 2]. Children with a family history of… read more here.
Keywords: detection; prenatal ultrasonographic; case; management ... See more keywords
Discovery of a transcriptomic core of genes shared in 8 primary retinoblastoma with a novel detection score analysis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-020-03266-y
Abstract: Purpose Expression microarrays are powerful technology that allows large-scale analysis of RNA profiles in a tissue; these platforms include underexploited detection scores outputs. We developed an algorithm using the detection score, to generate a detection… read more here.
Keywords: detection; analysis; retinoblastoma; detection score ... See more keywords
Sp1-mediated up-regulation of lnc00152 promotes invasion and metastasis of retinoblastoma cells via the miR-30d/SOX9/ZEB2 pathway
Sign Up to like & getrecommendations! Published in 2020 at "Cellular Oncology"
DOI: 10.1007/s13402-020-00522-8
Abstract: Purpose Previously, we found that long non-coding RNA (lncRNA) MEG3 may act as a tumour suppressor in retinoblastoma. Overall, however, little is known about the role of lncRNAs in retinoblastoma. Here, we aimed to determine… read more here.
Keywords: retinoblastoma cells; lnc00152; retinoblastoma; sox9 zeb2 ... See more keywords
Atypical intravitreal growth of retinoblastoma with a multi-branching configuration
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Ophthalmology Case Reports"
DOI: 10.1016/j.ajoc.2017.04.003
Abstract: Purpose To report the clinical and histopathological findings of atypical intravitreal growth of a retinoblastoma with a multi-branching configuration. Observations A 7-month-old boy was referred to our hospital due to leukocoria in the right eye.… read more here.
Keywords: retinoblastoma; growth; multi branching; branching configuration ... See more keywords
Reprogramming of retinoblastoma cancer cells into cancer stem cells.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2016.11.072
Abstract: Retinoblastoma is the most common intraocular malignancy in pediatric patients. It develops rapidly in the retina and can be fatal if not treated promptly. It has been proposed that a small population of cancer cells,… read more here.
Keywords: cancer stem; retinoblastoma; cancer cells; cancer ... See more keywords
microRNA-181a-5p impedes the proliferation, migration, and invasion of retinoblastoma cells by targeting the NRAS proto-oncogene
Sign Up to like & getrecommendations! Published in 2022 at "Clinics"
DOI: 10.1016/j.clinsp.2022.100026
Abstract: Highlights • miR-181a-5p expression was found to be decreased in retinoblastoma tissues and cell lines.• miR-181a-5p reduced retinoblastoma cell proliferation, migration, and invasion while enhancing apoptosis.• NRAS is a direct target of miR-181a-5p. read more here.
Keywords: proliferation migration; retinoblastoma; migration invasion;
Co‐delivery of miR‐181a and melphalan by lipid nanoparticles for treatment of seeded retinoblastoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2019.02.014
Abstract: Abstract Melphalan is an efficient chemotherapeutic agent that is currently used to treat retinoblastoma (Rb); however, the inherent risk of immunogenicity and the hazardous integration of this drug in healthy cells is inevitable. MicroRNAs are… read more here.
Keywords: melphalan; retinoblastoma; lipid nanoparticles; gene ... See more keywords
Modeling Developmental and Tumorigenic Aspects of Trilateral Retinoblastoma via Human Embryonic Stem Cells
Sign Up to like & getrecommendations! Published in 2017 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2017.03.005
Abstract: Summary Human embryonic stem cells (hESCs) provide a platform for studying human development and understanding mechanisms underlying diseases. Retinoblastoma-1 (RB1) is a key regulator of cell cycling, of which biallelic inactivation initiates retinoblastoma, the most… read more here.
Keywords: trilateral retinoblastoma; embryonic stem; retinoblastoma; stem ... See more keywords