Endothelial retinoblastoma protein reduces abdominal aortic aneurysm development via promoting DHFR/NO pathway-mediated vasoprotection
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-019-03567-y
Abstract: Cardiovascular disease (CVD) is a major cause of global mortality. The proper functioning of the endothelial layer of arteries is crucial to cardiovascular health. Retinoblastoma protein (Rb), encoded by the Rb1 gene, has been shown… read more here.
Keywords: aortic aneurysm; dhfr pathway; retinoblastoma protein; abdominal aortic ... See more keywords
A masked initiation region in retinoblastoma protein regulates its proteasomal degradation
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-16003-3
Abstract: Retinoblastoma protein (Rb) is a tumor suppressor that binds and represses E2F transcription factors. In cervical cancer cells, human papilloma virus (HPV) protein E7 binds to Rb, releasing it from E2F to promote cell cycle… read more here.
Keywords: protein; degradation; retinoblastoma protein; proteasomal degradation ... See more keywords
Diversification of retinoblastoma protein function associated with cis and trans adaptations.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular biology and evolution"
DOI: 10.1093/molbev/msz187
Abstract: Retinoblastoma proteins are eukaryotic transcriptional co-repressors that play central roles in cell cycle control, among other functions. Although most metazoan genomes encode a single retinoblastoma protein, gene duplications have occurred at least twice: in the… read more here.
Keywords: diversification retinoblastoma; retinoblastoma; retinoblastoma protein; function ... See more keywords
Abstract 369: The retinoblastoma protein regulates glucose metabolism in lung cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-369
Abstract: Lung cancer is among the most frequently diagnosed cancers and is the leading cause of cancer-related deaths in the United States. Of its subtypes, non-small cell lung cancer (NSCLC) accounts for 85% of all lung… read more here.
Keywords: kras lslg12d; retinoblastoma protein; glucose metabolism; lung cancer ... See more keywords
Retinoblastoma protein promotes uterine epithelial cell cycle arrest and necroptosis for embryo invasion
Sign Up to like & getrecommendations! Published in 2021 at "EMBO reports"
DOI: 10.15252/embr.202050927
Abstract: Retinoblastoma protein (RB) encoded by Rb1 is a prominent inducer of cell cycle arrest (CCA). The hormone progesterone (P4) promotes CCA in the uterine epithelium and previous studies indicated that P4 activates RB by reducing… read more here.
Keywords: embryo invasion; necroptosis; embryo; retinoblastoma protein ... See more keywords
Effect of Vitamin D on Retinoblastoma Protein in Prediabetic Individuals.
Sign Up to like & getrecommendations! Published in 2023 at "Current diabetes reviews"
DOI: 10.2174/1573399819666230331083715
Abstract: About 50.8 million people were diagnosed with diabetes in 2011; the count has increased by 10 million in the last five years. Type-1 diabetes could occur at any age, but predominantly in children and young… read more here.
Keywords: cell; retinoblastoma; vitamin; type diabetes ... See more keywords