A mouse model of MYCN-driven retinoblastoma reveals MYCN-independent tumor reemergence
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DOI: 10.1172/jci88508
Abstract: The most frequent focal alterations in human retinoblastoma are mutations in the tumor-suppressor gene retinoblastoma (RB) and amplification of the oncogene MYCN. Whether MYCN overexpression drives retinoblastoma has not been assessed in model systems. Here,… read more here.
Keywords: retinoblastoma reveals; mycn driven; retinoblastoma; model ... See more keywords