EZH2 modulates retinoic acid signaling to ensure myotube formation during development
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14334
Abstract: Sequential differentiation of presomitic progenitors into myocytes and subsequently into myotubes and myofibers is essential for the myogenic differentiation program (MDP) crucial for muscle development. Signaling factors involved in MDP are polycomb repressive complex 2… read more here.
Keywords: myocyte differentiation; development; retinoic acid; differentiation ... See more keywords
Induction of Nephron–Ductal Dual Lineages via Early Retinoic Acid Signaling Establishes a Platform for Fully Patterned Kidney Organoids
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202502044
Abstract: Kidney organoids are powerful tools for renal disease modeling and nephrotoxicity screening, yet their limited structural complexity—particularly the underdevelopment of ureteric bud (UB) lineages—remains a major limitation. A novel differentiation protocol is developed that short‐term… read more here.
Keywords: retinoic acid; culture; kidney organoids; acid signaling ... See more keywords
Investigation of selective retinoic acid receptor alpha antagonist ER-50891 and related analogs for male contraception.
Sign Up to like & getrecommendations! Published in 2023 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202300031
Abstract: Retinoic acid receptor alpha (RARα) antagonist ER-50891 and 15 analogs were prepared and tested in vitro for potency and selectivity at RARα, RARβ, and RARγ using transactivation assays. Minor modifications to the parent molecule such… read more here.
Keywords: receptor alpha; antagonist 50891; retinoic acid; acid receptor ... See more keywords
Impairment of Retinoic Acid Signaling in Cornelia de Lange Syndrome Fibroblasts.
Sign Up to like & getrecommendations! Published in 2017 at "Birth defects research"
DOI: 10.1002/bdr2.1070
Abstract: BACKGROUND Cornelia de Lange syndrome (CdLS) is a rare genetic disorder affecting the neurodevelopment, gastrointestinal, musculoskeletal systems. CdLS is caused by mutations within NIPBL, SMC1A, SMC3, RAD21, and HDAC8 genes. These genes codify for the… read more here.
Keywords: cdls patients; lange syndrome; treatment; acid signaling ... See more keywords
Production of retinoic acid by engineered Saccharomyces cerevisiae using an endogenous aldehyde dehydrogenase
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28192
Abstract: Retinoic acid (RA), a vitamin A (retinol)‐derived lipophilic compound, is involved in various physiological functions. The demand for RA is growing in the pharmaceutical industry, but RA biosynthesis is still in its infancy compared to… read more here.
Keywords: aldehyde dehydrogenase; dehydrogenase; retinoic acid; endogenous aldehyde ... See more keywords
Chronic retinoic acid treatment induces differentiation and changes in the metabolite levels of brown (pre)adipocytes
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3416
Abstract: Dietary vitamin A status affects energy metabolism. The present study explored the effect of all‐trans retinoic acid (ATRA) on the expression levels of molecules and metabolites of brown adipocytes. Chronic ATRA treatment was initiated during… read more here.
Keywords: treatment; expression; retinoic acid; day ... See more keywords
Retinoic acid reduces kidney injury by regulating oxidative stress, NRF‐2, and apoptosis in hyperoxic mice
Sign Up to like & getrecommendations! Published in 2024 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.4094
Abstract: Nuclear factor‐erythroid‐2‐related factor‐2 (NRF‐2) is a cellular resistance protein to oxidants. We investigated the effect of exogenous all‐trans retinoic acid (ATRA) on the antioxidant system and NRF‐2 in mice kidneys under hyperoxia‐induced oxidative stress. Mice… read more here.
Keywords: retinoic acid; hyperoxic mice; stress; oxidative stress ... See more keywords
Protective effect of retinoic acid receptor α on hypoxia‐induced epithelial to mesenchymal transition of renal tubular epithelial cells associated with TGF‐β/MMP‐9 pathway
Sign Up to like & getrecommendations! Published in 2018 at "Cell Biology International"
DOI: 10.1002/cbin.10982
Abstract: Retinoic acid receptor α (RARα), a member of family of the nuclear retinoic acid receptors (RARs), plays an essential role in various chronic kidney diseases (CKD). Renal tubular epithelial to mesenchymal transition (EMT) is a… read more here.
Keywords: tgf mmp; retinoic acid; renal tubular; tubular epithelial ... See more keywords
RXRα and MRTF‐A have a synergistic effect in the retinoic acid‐induced neural‐like differentiation of adult bone marrow‐derived mesenchymal stem cells
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biology International"
DOI: 10.1002/cbin.11331
Abstract: Mesenchymal stem cells (MSCs) have multilineage differentiation potential and can transform into neuron cells under an appropriate environment. Retinoic acid (RA) facilitates the neuronal differentiation of MSCs. We found that RXRα, a RA receptor, was… read more here.
Keywords: differentiation; rxr mrtf; retinoic acid; stem cells ... See more keywords
The effect of all‐trans retinoic acid on the mitochondrial function and survival of cardiomyoblasts exposed to local photodamage
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11784
Abstract: Using H9C2 cardiomyoblasts, we have shown that all‐trans retinoic acid (ATRA), the biologically active metabolite of vitamin A, affects mitochondrial dynamics and functions. The low dose (10 nM) ATRA stimulates the expression of nuclear retinoid receptors… read more here.
Keywords: effect; survival; retinoic acid; cells treated ... See more keywords
Retinoic acid receptor gamma is required for proliferation of pancreatic cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11917
Abstract: Despite the expectation that retinoic acid receptor could be the potential therapeutic targets for pancreatic cancers, there has been the lack of information about the role and the impact of retinoic acid receptor gamma (RARγ,… read more here.
Keywords: proliferation; pancreatic cancer; retinoic acid; acid receptor ... See more keywords