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Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14334
Abstract: Sequential differentiation of presomitic progenitors into myocytes and subsequently into myotubes and myofibers is essential for the myogenic differentiation program (MDP) crucial for muscle development. Signaling factors involved in MDP are polycomb repressive complex 2…
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Keywords:
myocyte differentiation;
development;
retinoic acid;
differentiation ... See more keywords
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Published in 2023 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202300031
Abstract: Retinoic acid receptor alpha (RARα) antagonist ER-50891 and 15 analogs were prepared and tested in vitro for potency and selectivity at RARα, RARβ, and RARγ using transactivation assays. Minor modifications to the parent molecule such…
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Keywords:
receptor alpha;
antagonist 50891;
retinoic acid;
acid receptor ... See more keywords
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Published in 2017 at "Birth defects research"
DOI: 10.1002/bdr2.1070
Abstract: BACKGROUND Cornelia de Lange syndrome (CdLS) is a rare genetic disorder affecting the neurodevelopment, gastrointestinal, musculoskeletal systems. CdLS is caused by mutations within NIPBL, SMC1A, SMC3, RAD21, and HDAC8 genes. These genes codify for the…
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Keywords:
cdls patients;
lange syndrome;
treatment;
acid signaling ... See more keywords
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Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28192
Abstract: Retinoic acid (RA), a vitamin A (retinol)‐derived lipophilic compound, is involved in various physiological functions. The demand for RA is growing in the pharmaceutical industry, but RA biosynthesis is still in its infancy compared to…
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Keywords:
aldehyde dehydrogenase;
dehydrogenase;
retinoic acid;
endogenous aldehyde ... See more keywords
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Published in 2019 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3416
Abstract: Dietary vitamin A status affects energy metabolism. The present study explored the effect of all‐trans retinoic acid (ATRA) on the expression levels of molecules and metabolites of brown adipocytes. Chronic ATRA treatment was initiated during…
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Keywords:
treatment;
expression;
retinoic acid;
day ... See more keywords
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Published in 2018 at "Cell Biology International"
DOI: 10.1002/cbin.10982
Abstract: Retinoic acid receptor α (RARα), a member of family of the nuclear retinoic acid receptors (RARs), plays an essential role in various chronic kidney diseases (CKD). Renal tubular epithelial to mesenchymal transition (EMT) is a…
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Keywords:
tgf mmp;
retinoic acid;
renal tubular;
tubular epithelial ... See more keywords
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Published in 2020 at "Cell Biology International"
DOI: 10.1002/cbin.11331
Abstract: Mesenchymal stem cells (MSCs) have multilineage differentiation potential and can transform into neuron cells under an appropriate environment. Retinoic acid (RA) facilitates the neuronal differentiation of MSCs. We found that RXRα, a RA receptor, was…
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Keywords:
differentiation;
rxr mrtf;
retinoic acid;
stem cells ... See more keywords
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Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11784
Abstract: Using H9C2 cardiomyoblasts, we have shown that all‐trans retinoic acid (ATRA), the biologically active metabolite of vitamin A, affects mitochondrial dynamics and functions. The low dose (10 nM) ATRA stimulates the expression of nuclear retinoid receptors…
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Keywords:
effect;
survival;
retinoic acid;
cells treated ... See more keywords
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Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11917
Abstract: Despite the expectation that retinoic acid receptor could be the potential therapeutic targets for pancreatic cancers, there has been the lack of information about the role and the impact of retinoic acid receptor gamma (RARγ,…
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Keywords:
proliferation;
pancreatic cancer;
retinoic acid;
acid receptor ... See more keywords
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Published in 2022 at "Developmental Dynamics"
DOI: 10.1002/dvdy.510
Abstract: The vitamin A derivative all‐trans retinoic acid (RA) regulates early stages of inner ear development. As the early disruption of the RA pathway results in profound mispatterning of the developing inner ear, this confounds analyses…
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Keywords:
signaling regulates;
inner ear;
acid signaling;
retinoic acid ... See more keywords
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Published in 2019 at "genesis"
DOI: 10.1002/dvg.23278
Abstract: Fetal Alcohol Spectrum Disorder (FASD) is a set of neurodevelopmental malformations caused by maternal consumption of alcohol during pregnancy. FASD sentinel facial features are unique to the disorder, and microcephaly is common in severe forms…
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Keywords:
craniofacial malformations;
acid deficiency;
retinoic acid;
deficiency ... See more keywords