Synthetic Retinoid Kills Drug‐Resistant Cancer Stem Cells via Inducing RARγ‐Translocation‐Mediated Tension Reduction and Chromatin Decondensation
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DOI: 10.1002/advs.202203173
Abstract: A recently developed synthetic retinoid abrogates proliferation and induces apoptosis of drug‐resistant malignant‐cancer‐stem‐cell‐like cells. However, the underlying mechanisms of how the synthetic retinoid induces cancer‐stem‐cell‐like cell tumor‐repopulating cell (TRC) apoptosis are elusive. Here, it is… read more here.
Keywords: cancer stem; synthetic retinoid; tension; retinoid ... See more keywords
Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice
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DOI: 10.1038/srep43782
Abstract: Fibroblast growth factor 21 (FGF21) has emerged as an important beneficial regulator of glucose and lipid homeostasis but its levels are also abnormally increased in insulin-resistant states in rodents and humans. The synthetic retinoid Fenretinide… read more here.
Keywords: insulin; fenretinide; fibroblast growth; fgf21 ... See more keywords
Hepatic Detoxification of Bisphenol A is Retinoid‐Dependent
Sign Up to like & getrecommendations! Published in 2017 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfx022
Abstract: &NA; Bisphenol A (BPA, 2,2‐bis(4‐hydroxyphenyl) propane) is a widely used industrial chemical. The extensive distribution of BPA in the environment poses risks to humans. However, the molecular mechanisms underlying BPA toxicity as well as its… read more here.
Keywords: bisphenol; bpa; detoxification; retinoid ... See more keywords
Alcohol induced hepatic retinoid depletion is associated with the induction of multiple retinoid catabolizing cytochrome P450 enzymes
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DOI: 10.1371/journal.pone.0261675
Abstract: Chronic alcohol consumption leads to a spectrum of liver disease that is associated with significant global mortality and morbidity. Alcohol is known to deplete hepatic vitamin A content, which has been linked to the pathogenesis… read more here.
Keywords: retinoid; hepatic vitamin; depletion; retinoid catabolizing ... See more keywords
A Phase 1 Study of IRX195183, a RARα-Selective CYP26 Resistant Retinoid, in Patients With Relapsed or Refractory AML
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DOI: 10.3389/fonc.2020.587062
Abstract: Subsets of non-acute promyelocytic leukemia (APL) acute myelogenous leukemia (AML) exhibit aberrant retinoid signaling and demonstrate sensitivity to retinoids in vitro. We present the results of a phase 1 dose-escalation study that evaluated the safety,… read more here.
Keywords: relapsed refractory; mds aml; study; retinoid ... See more keywords
Peretinoin, an Acyclic Retinoid, for the Secondary Prevention of Hepatocellular Carcinoma
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DOI: 10.3390/molecules26020295
Abstract: The high rates of hepatocellular carcinoma (HCC) recurrence after initially successful curative therapy emphasize ongoing unmet needs to prevent or reduce HCC recurrence. Retinoid acid (RA), a metabolite of vitamin A and its related analogues… read more here.
Keywords: hepatocellular carcinoma; peretinoin acyclic; acyclic retinoid; retinoid secondary ... See more keywords