A facile synthetic approach to 3-halo-4-substituted-1,5-dihydro-4 H -1,2,4-triazoline-5-thiones based on retro-Michael addition
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DOI: 10.1007/s40242-017-6491-5
Abstract: A facile 3-step synthetic approach to 3-halo-4-substituted-1,5-dihydro-4H-1,2,4-triazoline-5-thiones (1a—1k) from corresponding unhalogenated 8a—8i was developed based on the strategy of retro-Michael addition, with the key steps being regioselective S-alkylation of compounds 8a—8i with ethyl 3-iodopropionate(12c) and… read more here.
Keywords: synthetic approach; michael addition; retro michael;
Discovery of Presaccharothriolide X, a Retro-Michael Reaction Product of Saccharothriolide B, from the Rare Actinomycete Saccharothrix sp. A1506.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b01535
Abstract: The highly reactive precursor molecule, presaccharothriolide X, was successfully isolated from the rare actinomycete Saccharothrix sp. A1506. The comparable biological activity of presaccharothriolide X and its Michael addition product saccharothriolide B unveils a unique masking/activating… read more here.
Keywords: rare actinomycete; saccharothrix a1506; retro michael; michael reaction ... See more keywords