Inhibition of SARS-CoV-2 Infection by Human Defensin HNP1 and Retrocyclin RC-101
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Biology"
DOI: 10.1016/j.jmb.2021.167225
Abstract: Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 is an enveloped virus responsible for the COVID-19 pandemic. The emergence of new potentially more transmissible and vaccine-resistant variants of SARS-CoV-2 is an ever-present threat. Thus, it remains essential… read more here.
Keywords: hnp1; cov infection; sars cov; retrocyclin 101 ... See more keywords
Mechanism through Which Retrocyclin Targets Flavivirus Multiplication
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DOI: 10.1128/jvi.00560-21
Abstract: Retrocyclin is an artificially humanized circular θ-defensin peptide, containing 18 residues, previously reported to possess broad antimicrobial activity. In this study, we found that retrocyclin-101 inhibited flavivirus (ZIKV and JEV) infections. Retrocyclin-101 inhibited NS2B-NS3 serine… read more here.
Keywords: flavivirus; activity; 101 inhibited; protease ... See more keywords
The θ‐defensin retrocyclin 101 inhibits TLR4‐ and TLR2‐dependent signaling and protects mice against influenza infection
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Leukocyte Biology"
DOI: 10.1189/jlb.2a1215-567rr
Abstract: Despite widespread use of annual influenza vaccines, seasonal influenza‐associated deaths number in the thousands each year, in part because of exacerbating bacterial superinfections. Therefore, discovering additional therapeutic options would be a valuable aid to public… read more here.
Keywords: defensin; retrocyclin 101; infection; influenza ... See more keywords