Genetic interaction between F‐box motif encoding YDR131C and retrograde signaling‐related RTG1 regulates the stress response and apoptosis in Saccharomyces cerevisiae
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22864
Abstract: The retrograde signaling pathway is well conserved from yeast to humans, which regulates cell adaptation during stress conditions and prevents cell death. One of its components, RTG1 encoded Rtg1p in association with Rtg3p communicates between… read more here.
Keywords: saccharomyces cerevisiae; retrograde signaling; box motif; interaction ... See more keywords
Overexpression of a single ORF can extend chronological lifespan in yeast if retrograde signaling and stress response are stimulated
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DOI: 10.1007/s10522-021-09924-z
Abstract: Systematic collections of single-gene deletions have been invaluable in uncovering determinants of lifespan in yeast. Overexpression of a single gene does not have such a clear outcome as cancellation of its function but it can… read more here.
Keywords: overexpression; retrograde signaling; overexpression single; chronological lifespan ... See more keywords
Gene expression analysis reveals function of TERF1 in plastid-nucleus retrograde signaling under drought stress conditions
Sign Up to like & getrecommendations! Published in 2018 at "Biologia Plantarum"
DOI: 10.1007/s10535-018-0771-x
Abstract: Ethylene response factor (ERF) is a key transcription factor of plant ethylene signaling pathway, which plays an important role in plant response to abiotic and biotic stresses by regulating the expression of downstream genes. However,… read more here.
Keywords: retrograde signaling; gene expression; expression; drought stress ... See more keywords
The PAP/SAL1 retrograde signaling pathway is involved in iron homeostasis
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DOI: 10.1007/s11103-019-00950-7
Abstract: Key message There is a link between PAP/SAL retrograde pathway, ethylene signaling and Fe metabolism in Arabidopsis. Abstract Nuclear gene expression is regulated by a diversity of retrograde signals that travel from organelles to the… read more here.
Keywords: retrograde signaling; pap sal1; sal1 retrograde; mutant plants ... See more keywords
Retrograde signaling via axonal transport through signaling endosomes.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2019.10.001
Abstract: Neurons extend axons far from cell bodies, and retrograde communications from distal axons to cell bodies and/or dendrites play critical roles in the development and maintenance of neuronal circuits. In neurotrophin signaling, the retrograde axonal… read more here.
Keywords: neurotrophin signaling; retrograde signaling; signaling endosomes; axonal transport ... See more keywords
Oxidative bursts of single mitochondria mediate retrograde signaling toward the ER.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.07.014
Abstract: The emerging role of mitochondria as signaling organelles raises the question of whether individual mitochondria can initiate heterotypic communication with neighboring organelles. Using fluorescent probes targeted to the endoplasmic-reticulum-mitochondrial interface, we demonstrate that single mitochondria… read more here.
Keywords: mitochondria mediate; single mitochondria; bursts single; retrograde signaling ... See more keywords
SDHA gain-of-function engages inflammatory mitochondrial retrograde signaling via KEAP1–Nrf2
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DOI: 10.1038/s41590-019-0482-2
Abstract: Whether screening the metabolic activity of immune cells facilitates discovery of molecular pathology remains unknown. Here we prospectively screened the extracellular acidification rate as a measure of glycolysis and the oxygen consumption rate as a… read more here.
Keywords: mitochondrial retrograde; keap1 nrf2; retrograde signaling; sdha gain ... See more keywords
Retrograde signaling by a mtDNA-encoded non-coding RNA preserves mitochondrial bioenergetics
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-01322-4
Abstract: Alveolar epithelial type II (AETII) cells are important for lung epithelium maintenance and function. We demonstrate that AETII cells from mouse lungs exposed to cigarette smoke (CS) increase the levels of the mitochondria-encoded non-coding RNA,… read more here.
Keywords: ncr 805; retrograde signaling; mito ncr; non coding ... See more keywords
Abstract 1491: Mitochondrial dysfunction from defective Cytochrome oxidase complex induces tumorigenic phenotype
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DOI: 10.1158/1538-7445.am2017-1491
Abstract: Mitochondrial defects that affect activity of the electron transport chain (ETC) complexes are associated with several diseases including cancer. Dysfunctional mitochondria resulting from mitochondrial DNA (mtDNA) alterations or exposure to xenobiotics have been shown to… read more here.
Keywords: cytochrome oxidase; oxidase; tumorigenic phenotype; cco ... See more keywords
Ras-ERK-ETS inhibition alleviates neuronal mitochondrial dysfunction by reprogramming mitochondrial retrograde signaling
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DOI: 10.1371/journal.pgen.1007567
Abstract: Mitochondrial dysfunction activates the mitochondrial retrograde signaling pathway, resulting in large scale changes in gene expression. Mitochondrial retrograde signaling in neurons is poorly understood and whether retrograde signaling contributes to cellular dysfunction or is protective… read more here.
Keywords: mitochondrial retrograde; erk ets; retrograde signaling; ras erk ... See more keywords
Role of the ISR-ATF4 pathway and its cross talk with Nrf2 in mitochondrial quality control
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Biochemistry and Nutrition"
DOI: 10.3164/jcbn.18-37
Abstract: Recent investigations have clarified the importance of mitochondria in various age-related degenerative diseases, including late-onset Alzheimer’s disease and Parkinson’s disease. Although mitochondrial disturbances can be involved in every step of disease progression, several observations have… read more here.
Keywords: isr atf4; mitochondrial retrograde; retrograde signaling; atf4 pathway ... See more keywords