A role for Rab30 in retrograde trafficking and maintenance of endosome-TGN organization.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.112442
Abstract: Rab30 is a poorly characterized small GTPase. Here we show that Rab30 is localized primarily to the TGN and recycling endosomes in a range of cell types, including primary neurons; minor levels of Rab30 were… read more here.
Keywords: rab30; endosome tgn; role rab30; tgn organization ... See more keywords
Cigarette Smoke Exposure Induces Retrograde Trafficking of CFTR to the Endoplasmic Reticulum
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-49544-9
Abstract: Chronic obstructive pulmonary disease (COPD), which is most commonly caused by cigarette smoke (CS) exposure, is the third leading cause of death worldwide. The cystic fibrosis transmembrane conductance regulator (CFTR) is an apical membrane anion… read more here.
Keywords: cftr; smoke exposure; cigarette smoke; exposure ... See more keywords
Rab6 regulates recycling and retrograde trafficking of MR1 molecules
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-77563-4
Abstract: Mucosal-associated invariant T (MAIT) cells are an innate-like T cell subset important in the early response to bacterial and viral lung pathogens. MAIT cells recognize bacterial small molecule metabolites presented on the Class I-like molecule… read more here.
Keywords: mr1 molecules; mait cells; recycling retrograde; regulates recycling ... See more keywords
An extended motif in the SARS-CoV-2 spike modulates binding and release of host coatomer in retrograde trafficking
Sign Up to like & getrecommendations! Published in 2022 at "Communications Biology"
DOI: 10.1038/s42003-022-03063-y
Abstract: β-Coronaviruses such as SARS-CoV-2 hijack coatomer protein-I (COPI) for spike protein retrograde trafficking to the progeny assembly site in endoplasmic reticulum-Golgi intermediate compartment (ERGIC). However, limited residue-level details are available into how the spike interacts… read more here.
Keywords: coatomer; copi; retrograde trafficking; sars cov ... See more keywords
Humanised monoclonal antibodies neutralise pertussis toxin by receptor blockade and reduced retrograde trafficking
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Microbiology"
DOI: 10.1111/cmi.12948
Abstract: Pertussis toxin (PTx) is a major protective antigen produced by Bordetella pertussis that is included in all current acellular vaccines. Of several well‐characterized monoclonal antibodies binding this toxin, the humanised hu1B7 and hu11E6 antibodies are… read more here.
Keywords: receptor; pertussis toxin; ptx; retrograde trafficking ... See more keywords
A PGAM5–KEAP1–Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Science"
DOI: 10.1242/jcs.203216
Abstract: ABSTRACT The Nrf2 transcription factor is a master regulator of the cellular anti-stress response. A population of the transcription factor associates with the mitochondria through a complex with KEAP1 and the mitochondrial outer membrane histidine… read more here.
Keywords: stress; keap1 nrf2; retrograde trafficking; pgam5 keap1 ... See more keywords
A Role for Drosophila Amyloid Precursor Protein in Retrograde Trafficking of L1-Type Cell Adhesion Molecule Neuroglian
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2019.00322
Abstract: The role of the Amyloid Precursor Protein (APP) in the pathology of Alzheimer’s disease (AD) has been well studied. However, the normal function of APP in the nervous system is poorly understood. Here, we characterized… read more here.
Keywords: precursor protein; role; amyloid precursor; function ... See more keywords