Oxidative Stress Triggers Selective tRNA Retrograde Transport in Human Cells during the Integrated Stress Response
Sign Up to like & getrecommendations! Published in 2019 at "Cell Reports"
DOI: 10.1016/j.celrep.2019.02.077
Abstract: Summary In eukaryotes, tRNAs are transcribed in the nucleus and exported to the cytosol, where they deliver amino acids to ribosomes for protein translation. This nuclear-cytoplasmic movement was believed to be unidirectional. However, active shuttling… read more here.
Keywords: trna retrograde; stress; retrograde transport; human cells ... See more keywords
Inhibition of retrograde transport modulates misfolded protein accumulation and clearance in motoneuron diseases
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DOI: 10.1080/15548627.2017.1308985
Abstract: ABSTRACT Motoneuron diseases, like spinal bulbar muscular atrophy (SBMA) and amyotrophic lateral sclerosis (ALS), are associated with proteins that because of gene mutation or peculiar structures, acquire aberrant (misfolded) conformations toxic to cells. To prevent… read more here.
Keywords: accumulation; retrograde transport; inhibition; misfolded protein ... See more keywords
Inhibition of JC polyomavirus infectivity by the retrograde transport inhibitor Retro‐2.1
Sign Up to like & getrecommendations! Published in 2020 at "Microbiology and Immunology"
DOI: 10.1111/1348-0421.12851
Abstract: JC polyomavirus (JCPyV) is a common human pathogen that results in a chronic asymptomatic infection in healthy adults. Under conditions of immunosuppression, JCPyV spreads to the central nervous system and can cause the fatal demyelinating… read more here.
Keywords: retrograde transport; infection; infectivity; polyomavirus ... See more keywords
Retrograde transport of CDMPR depends on several machineries as analyzed by sulfatable nanobodies.
Sign Up to like & getrecommendations! Published in 2022 at "Life science alliance"
DOI: 10.26508/lsa.202101269
Abstract: Retrograde protein transport from the cell surface and endosomes to the TGN is essential for membrane homeostasis in general and for the recycling of mannose-6-phosphate receptors (MPRs) for sorting of lysosomal hydrolases in particular. We… read more here.
Keywords: transport cdmpr; depends several; cdmpr depends; transport ... See more keywords
Protein sorting from endosomes to the TGN
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DOI: 10.3389/fcell.2023.1140605
Abstract: Retrograde transport from endosomes to the trans-Golgi network is essential for recycling of protein and lipid cargoes to counterbalance anterograde membrane traffic. Protein cargo subjected to retrograde traffic include lysosomal acid-hydrolase receptors, SNARE proteins, processing… read more here.
Keywords: sorting endosomes; protein sorting; transport; retrograde transport ... See more keywords
Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer’s disease neurons
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DOI: 10.7554/elife.21776
Abstract: Neurons face unique challenges of transporting nascent autophagic vacuoles (AVs) from distal axons toward the soma, where mature lysosomes are mainly located. Autophagy defects have been linked to Alzheimer’s disease (AD). However, the mechanisms underlying… read more here.
Keywords: retrograde transport; autophagic stress; alzheimer disease; stress ... See more keywords