EMAC, Retromer, and VSRs: do they connect?
Sign Up to like & getrecommendations! Published in 2020 at "Protoplasma"
DOI: 10.1007/s00709-020-01543-8
Abstract: Eukaryotic organisms share many common features in terms of endomembrane trafficking. This fact has helped plant scientists to propose testable hypotheses on how plant intracellular membrane trafficking is achieved and regulated based on knowledge from… read more here.
Keywords: emac retromer; plant; retromer; retromer vsrs ... See more keywords
All ways lead to Rome: assembly of retromer on membranes with different sorting nexins
Sign Up to like & getrecommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-021-00561-z
Abstract: In a recent paper published in Science Advances, Leneva et al. present cryo-electron tomography structures of assembling metazoan and fungal core retromer complexes (VPS29/VPS35/ VPS26) on membranes enriched in Øx(L/M/V) motif (where Ø is a… read more here.
Keywords: retromer; bar; snx bars; structure ... See more keywords
Retromer dysfunction in amyotrophic lateral sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2118755119
Abstract: Significance Amyotrophic lateral sclerosis is an adult-onset paralytic disorder whose mechanism remains uncertain. In this work, we report a defect in the retromer complex, which plays a crucial role in endosomal protein sorting and trafficking… read more here.
Keywords: retromer; dysfunction amyotrophic; lateral sclerosis; retromer dysfunction ... See more keywords
A plant-unique protein BLISTER coordinates with core retromer to modulate endosomal sorting of plasma membrane and vacuolar proteins.
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2211258120
Abstract: The retromer is a heteromeric protein complex that localizes to endosomal membranes and drives the formation of endosomal tubules that recycle membrane protein cargoes. In plants, the retromer plays essential and canonical functions in regulating… read more here.
Keywords: retromer; membrane; protein; plant ... See more keywords
Retromer regulates the lysosomal clearance of MAPT/tau
Sign Up to like & getrecommendations! Published in 2020 at "Autophagy"
DOI: 10.1080/15548627.2020.1821545
Abstract: ABSTRACT The macroautophagy/autophagy-lysosome axis enables the clearance and degradation of cytoplasmic components including protein aggregates, damaged organelles and invading pathogens. Protein aggregation and lysosomal system dysfunction in the brain are common features of several late-onset… read more here.
Keywords: mapt tau; aggregation; retromer; clearance ... See more keywords
Vacuole fragmentation depends on a novel Atg18-containing retromer-complex
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2072656
Abstract: ABSTRACT The yeast PROPPIN Atg18 folds as a β-propeller with two binding sites for phosphatidylinositol-3-phosphate (PtdIns3P) and PtdIns(3,5)P2 at its circumference. Membrane insertion of an amphipathic loop of Atg18 leads to membrane tubulation and fission.… read more here.
Keywords: retromer; retromer complex; vacuole fragmentation; fragmentation depends ... See more keywords
RAB21 controls autophagy and cellular energy homeostasis by regulating retromer-mediated recycling of SLC2A1/GLUT1
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2114271
Abstract: ABSTRACT The endosomal system maintains cellular homeostasis by coordinating multiple vesicular trafficking events, and the retromer complex plays a critical role in endosomal cargo recognition and sorting. Here, we demonstrate an essential role for the… read more here.
Keywords: retromer; rab21; rab21 depletion; energy ... See more keywords
Retromer facilitates the localization of Bcl-xL to the mitochondrial outer membrane
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e19-01-0044
Abstract: The anti-apoptotic Bcl-2 family protein Bcl-xL plays a critical role in cell survival by protecting the integrity of the mitochondrial outer membrane (MOM). The mechanism through which Bcl-xL is recruited to the MOM has not… read more here.
Keywords: mitochondrial outer; outer membrane; retromer; membrane ... See more keywords
Impaired axonal retrograde trafficking of the retromer complex augments lysosomal deficits in Alzheimer’s disease neurons
Sign Up to like & getrecommendations! Published in 2017 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddx321
Abstract: Lysosomal proteolysis is essential for the quality control of intracellular components and the maintenance of cellular homeostasis. Lysosomal alterations have been implicated as one of the main cellular defects contributing to the onset and progression… read more here.
Keywords: retrograde; lysosomal deficits; alzheimer disease; retromer ... See more keywords
Multi-omic approach characterises the neuroprotective role of retromer in regulating lysosomal health
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1101/2022.09.13.507260
Abstract: Retromer controls cellular homeostasis through regulating integral membrane protein sorting and transport and by controlling late-stage maturation of the endo-lysosomal network. Retromer dysfunction, which is linked to neurodegenerative disorders including Parkinson’s and Alzheimer’s diseases, manifests… read more here.
Keywords: retromer; regulating lysosomal; dysfunction; lysosomal health ... See more keywords
Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly
Sign Up to like & getrecommendations! Published in 2021 at "Science Advances"
DOI: 10.1126/sciadv.abf8598
Abstract: Cryo–electron tomography shows how retromer recruits cargo and tubulates endosomes without canonical membrane-bending proteins. Retromer is a master regulator of cargo retrieval from endosomes, which is critical for many cellular processes including signaling, immunity, neuroprotection,… read more here.
Keywords: architecture mechanism; mechanism metazoan; retromer; snx3 ... See more keywords