Dysregulation of the Retromer Complex System in Down Syndrome
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Neurology"
DOI: 10.1002/ana.25752
Abstract: Most of the patients with Down syndrome (DS) develop Alzheimer's disease (AD) neuropathology by age 40. Although this increased susceptibility to AD in DS is thought to be primarily due to triplication of the amyloid… read more here.
Keywords: dysregulation retromer; retromer complex; complex system;
The understudied links of the retromer complex to age-related pathways.
Sign Up to like & getrecommendations! Published in 2021 at "GeroScience"
DOI: 10.1007/s11357-021-00430-1
Abstract: Neuronal aging is associated with numerous diseases resulting in memory impairment and functional decline. A common hallmark of these disorders is the accumulation of intracellular and extracellular protein aggregates. The retromer complex plays a central… read more here.
Keywords: age related; links retromer; age; retromer complex ... See more keywords
Vacuole fragmentation depends on a novel Atg18-containing retromer-complex
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2072656
Abstract: ABSTRACT The yeast PROPPIN Atg18 folds as a β-propeller with two binding sites for phosphatidylinositol-3-phosphate (PtdIns3P) and PtdIns(3,5)P2 at its circumference. Membrane insertion of an amphipathic loop of Atg18 leads to membrane tubulation and fission.… read more here.
Keywords: retromer; retromer complex; vacuole fragmentation; fragmentation depends ... See more keywords
VPS35, the Retromer Complex and Parkinson’s Disease
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DOI: 10.3233/jpd-161020
Abstract: Mutations in the vacuolar protein sorting 35 ortholog (VPS35) gene encoding a core component of the retromer complex, have recently emerged as a new cause of late-onset, autosomal dominant familial Parkinson’s disease (PD). A single… read more here.
Keywords: vps35 retromer; retromer complex; retromer; parkinson disease ... See more keywords
Updated Insight into the Physiological and Pathological Roles of the Retromer Complex
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DOI: 10.3390/ijms18081601
Abstract: Retromer complexes mediate protein trafficking from the endosomes to the trans-Golgi network (TGN) or through direct recycling to the plasma membrane. In yeast, they consist of a conserved trimer of the cargo selective complex (CSC),… read more here.
Keywords: physiological pathological; retromer complex; insight physiological; pathological roles ... See more keywords