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   Articles with "retromer complex" as a keyword



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Dysregulation of the Retromer Complex System in Down Syndrome

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recommendations! Published in 2020 at "Annals of Neurology"

DOI: 10.1002/ana.25752

Abstract: Most of the patients with Down syndrome (DS) develop Alzheimer's disease (AD) neuropathology by age 40. Although this increased susceptibility to AD in DS is thought to be primarily due to triplication of the amyloid… read more here.

Keywords: dysregulation retromer; retromer complex; complex system;
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The understudied links of the retromer complex to age-related pathways.

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recommendations! Published in 2021 at "GeroScience"

DOI: 10.1007/s11357-021-00430-1

Abstract: Neuronal aging is associated with numerous diseases resulting in memory impairment and functional decline. A common hallmark of these disorders is the accumulation of intracellular and extracellular protein aggregates. The retromer complex plays a central… read more here.

Keywords: age related; links retromer; age; retromer complex ... See more keywords

Vacuole fragmentation depends on a novel Atg18-containing retromer-complex

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recommendations! Published in 2022 at "Autophagy"

DOI: 10.1080/15548627.2022.2072656

Abstract: ABSTRACT The yeast PROPPIN Atg18 folds as a β-propeller with two binding sites for phosphatidylinositol-3-phosphate (PtdIns3P) and PtdIns(3,5)P2 at its circumference. Membrane insertion of an amphipathic loop of Atg18 leads to membrane tubulation and fission.… read more here.

Keywords: retromer; retromer complex; vacuole fragmentation; fragmentation depends ... See more keywords

Scorpion venom heat‐resistant synthetic peptide improves cognitive dysfunction of APP/PS1 mice through microglial retromer complex

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recommendations! Published in 2025 at "British Journal of Pharmacology"

DOI: 10.1111/bph.70124

Abstract: The abnormal accumulation of amyloid‐β (Aβ) in the brain is a characteristic pathological change observed in patients with Alzheimer's disease (AD). Microglial phagocytosis, dependent on recycling through the retromer complex and cell membrane‐bound receptors, plays… read more here.

Keywords: heat resistant; scorpion venom; retromer; resistant synthetic ... See more keywords

VPS35, the Retromer Complex and Parkinson’s Disease

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recommendations! Published in 2017 at "Journal of Parkinson's Disease"

DOI: 10.3233/jpd-161020

Abstract: Mutations in the vacuolar protein sorting 35 ortholog (VPS35) gene encoding a core component of the retromer complex, have recently emerged as a new cause of late-onset, autosomal dominant familial Parkinson’s disease (PD). A single… read more here.

Keywords: vps35 retromer; retromer complex; retromer; parkinson disease ... See more keywords

Planning for Prevention of Parkinson’s: A trial design forum

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recommendations! Published in 2024 at "Journal of Parkinson's Disease"

DOI: 10.3233/jpd-249002

Abstract: Background: We assessed the effects of a pharmacological approach to stabilize the retromer complex in a Parkinson’s disease (PD) mouse model. Mis-sense mutations in the VPS35 gene are a rare cause of familial PD. The… read more here.

Keywords: mouse model; planning prevention; retromer complex; parkinson ... See more keywords

Updated Insight into the Physiological and Pathological Roles of the Retromer Complex

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recommendations! Published in 2017 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms18081601

Abstract: Retromer complexes mediate protein trafficking from the endosomes to the trans-Golgi network (TGN) or through direct recycling to the plasma membrane. In yeast, they consist of a conserved trimer of the cargo selective complex (CSC),… read more here.

Keywords: physiological pathological; retromer complex; insight physiological; pathological roles ... See more keywords

The Sorting and Transport of the Cargo Protein CcSnc1 by the Retromer Complex Regulate the Growth, Development, and Pathogenicity of Corynespora cassiicola

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recommendations! Published in 2024 at "Journal of Fungi"

DOI: 10.3390/jof10100714

Abstract: In eukaryotes, the retromer complex is critical for the transport of cargo proteins from endosomes to the trans-Golgi network (TGN). Despite its importance, there is a lack of research on the retromer-mediated transport of cargo… read more here.

Keywords: retromer complex; transport cargo; transport; growth development ... See more keywords