Alpha-synuclein inhibits Snx3–retromer-mediated retrograde recycling of iron transporters in S. cerevisiae and C. elegans models of Parkinson’s disease
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DOI: 10.1093/hmg/ddy059
Abstract: We probed the role of alpha-synuclein (α-syn) in modulating sorting nexin 3 (Snx3)-retromer-mediated recycling of iron transporters in Saccharomyces cerevisiae and Caenorhabditis elegans. In yeast, the membrane-bound heterodimer Fet3/Ftr1 is the high affinity iron importer.… read more here.
Keywords: retromer mediated; snx3 retromer; fet3 ftr1; iron ... See more keywords
Navigating the Controversies of Retromer-Mediated Endosomal Protein Sorting
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.658741
Abstract: The retromer complex was first identified more than 20 years ago through studies conducted in the yeast Saccharomyces cerevisiae. Data obtained using many different model systems have revealed that retromer is a key component of… read more here.
Keywords: navigating controversies; retromer mediated; controversies retromer; endosomal protein ... See more keywords