PBTK model-based analysis of CYP3A4 induction and the toxicokinetics of the pyrrolizidine alkaloid retrorsine in man
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DOI: 10.1007/s00204-024-03698-2
Abstract: Cytochrome P450 (CYP)3A4 induction by drugs and pesticides plays a critical role in the enhancement of pyrrolizidine alkaloid (PA) toxicity as it leads to increased formation of hepatotoxic dehydro-PA metabolites. Addressing the need for a… read more here.
Keywords: pbtk model; cyp3a4; retrorsine; usepackage ... See more keywords