Derlin rhomboid pseudoproteases employ substrate engagement and lipid distortion to enable the retrotranslocation of ERAD membrane substrates.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109840
Abstract: Nearly one-third of proteins are initially targeted to the endoplasmic reticulum (ER) membrane, where they are correctly folded and then delivered to their final cellular destinations. To prevent the accumulation of misfolded membrane proteins, ER-associated… read more here.
Keywords: erad membrane; membrane substrates; rhomboid pseudoproteases; retrotranslocation ... See more keywords
A Retrotranslocation Assay That Predicts Defective VCP/p97-Mediated Trafficking of a Retroviral Signal Peptide
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DOI: 10.1128/mbio.02953-21
Abstract: Endoplasmic reticulum-associated degradation (ERAD) is a form of cellular protein quality control that is manipulated by viruses, including the betaretrovirus, mouse mammary tumor virus (MMTV). MMTV-encoded signal peptide (SP) has been shown to interact with… read more here.
Keywords: mmtv; signal peptide; retrotranslocation; vcp ... See more keywords
Parkin promotes proteasomal degradation of misregulated BAX
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DOI: 10.1242/jcs.200162
Abstract: ABSTRACT The pro-apoptotic BCL-2 protein BAX commits human cells to apoptosis by permeabilizing the outer mitochondrial membrane. BAX activation has been suggested to require the separation of helix α5 from α6 – the ‘latch’ from… read more here.
Keywords: bax; misregulated bax; pro apoptotic; retrotranslocation ... See more keywords