LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "retrotransposition" as a keyword



Photo by nci from unsplash

Heritable L1 Retrotransposition Events During Development: Understanding Their Origins

Sign Up to like & get
recommendations! Published in 2018 at "Bioessays"

DOI: 10.1002/bies.201700189

Abstract: The retrotransposon Long Interspersed Element 1 (LINE‐1 or L1) has played a major role in shaping the sequence composition of the mammalian genome. In our recent publication, “Heritable L1 retrotransposition in the mouse primordial germline… read more here.

Keywords: retrotransposition events; events development; retrotransposition; heritable retrotransposition ... See more keywords
Photo by rgaleriacom from unsplash

LINE‐1 vectors mediate recombinant antibody gene transfer by retrotransposition in Chinese hamster ovary cells

Sign Up to like & get
recommendations! Published in 2021 at "Biotechnology Journal"

DOI: 10.1002/biot.202000620

Abstract: Retrotransposons, such as long interspersed element‐1 (LINE‐1), can copy themselves to other genomic loci via a transposition event (termed retrotransposition). Retrotransposons, therefore, have potential use as an efficient gene delivery tool to integrate multiple copies… read more here.

Keywords: vectors mediate; line; mediate recombinant; line vectors ... See more keywords
Photo by richardrschunemann from unsplash

L1 retrotransposition alters the hippocampal genomic landscape enabling memory formation

Sign Up to like & get
recommendations! Published in 2017 at "Brain, Behavior, and Immunity"

DOI: 10.1016/j.bbi.2016.12.018

Abstract: Somatic LINE-1 (L1) retrotransposition is a source of genomic mosaicism and potential phenotypic diversity among neurons during brain development. In the adult brain, L1 expression can be triggered by different environmental alterations, but its functional… read more here.

Keywords: memory formation; retrotransposition; alters hippocampal; retrotransposition alters ... See more keywords
Photo by anniespratt from unsplash

Evaluating different DNA binding domains to modulate L1 ORF2p-driven site-specific retrotransposition events in human cells.

Sign Up to like & get
recommendations! Published in 2018 at "Gene"

DOI: 10.1016/j.gene.2017.11.033

Abstract: DNA binding domains (DBDs) have been used with great success to impart targeting capabilities to a variety of proteins creating highly useful genomic tools. We evaluated the ability of five types of DBDs and strategies… read more here.

Keywords: binding domains; retrotransposition; orf2p driven; dna binding ... See more keywords
Photo by nci from unsplash

Contribution of retrotransposition to developmental disorders

Sign Up to like & get
recommendations! Published in 2019 at "Nature Communications"

DOI: 10.1038/s41467-019-12520-y

Abstract: Mobile genetic Elements (MEs) are segments of DNA which can copy themselves and other transcribed sequences through the process of retrotransposition (RT). In humans several disorders have been attributed to RT, but the role of… read more here.

Keywords: retrotransposition developmental; retrotransposition; contribution retrotransposition; developmental disorders ... See more keywords
Photo from wikipedia

Characterization of an active LINE-1 in the naked mole-rat genome

Sign Up to like & get
recommendations! Published in 2021 at "Scientific Reports"

DOI: 10.1038/s41598-021-84962-8

Abstract: Naked mole-rats (NMRs, Heterocephalus glaber) are the longest-living rodent species. A reason for their long lifespan is pronounced cancer resistance. Therefore, researchers believe that NMRs have unknown secrets of cancer resistance and seek to find… read more here.

Keywords: nmr genome; cancer resistance; naked mole; retrotransposition ... See more keywords
Photo by dementedpixel from unsplash

The L1-ORF1p coiled coil enables formation of a tightly compacted nucleic acid-bound complex that is associated with retrotransposition

Sign Up to like & get
recommendations! Published in 2022 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkac628

Abstract: Abstract Long interspersed nuclear element 1 (L1) parasitized most vertebrates and constitutes ∼20% of the human genome. It encodes ORF1p and ORF2p which form an L1-ribonucleoprotein (RNP) with their encoding transcript that is copied into… read more here.

Keywords: retrotransposition; coiled coil; tightly compacted; nucleic acid ... See more keywords
Photo by erdaest from unsplash

A novel role of TRIM28 B box domain in L1 retrotransposition and ORF2p-mediated cDNA synthesis

Sign Up to like & get
recommendations! Published in 2023 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkad247

Abstract: Abstract The long interspersed element 1 (LINE-1 or L1) integration is affected by many cellular factors through various mechanisms. Some of these factors are required for L1 amplification, while others either suppress or enhance specific… read more here.

Keywords: box domain; retrotransposition; cdna synthesis; trim28 box ... See more keywords
Photo by alfiankurniawan1 from unsplash

HIV-1 Vpr and p21 restrict LINE-1 mobility

Sign Up to like & get
recommendations! Published in 2018 at "Nucleic Acids Research"

DOI: 10.1093/nar/gky688

Abstract: Abstract Long interspersed element-1 (LINE-1, L1) composes ∼17% of the human genome. However, genetic interactions between L1 and human immunodeficiency virus type 1 (HIV-1) remain poorly understood. In this study, we found that HIV-1 suppresses… read more here.

Keywords: vpr p21; retrotransposition; vpr; cell cycle ... See more keywords
Photo by matnapo from unsplash

The MOV10 RNA helicase is a dosage-dependent host restriction factor for LINE1 retrotransposition in mice

Sign Up to like & get
recommendations! Published in 2022 at "PLOS Genetics"

DOI: 10.1101/2022.12.13.520206

Abstract: Transposable elements constitute nearly half of the mammalian genome and play important roles in genome evolution. While a multitude of both transcriptional and post-transcriptional mechanisms exist to silence transposable elements, control of transposition in vivo… read more here.

Keywords: mov10 rna; line1 retrotransposition; retrotransposition; mov10 ... See more keywords
Photo from wikipedia

Immune signatures correlate with L1 retrotransposition in gastrointestinal cancers.

Sign Up to like & get
recommendations! Published in 2018 at "Genome research"

DOI: 10.1101/gr.231837.117

Abstract: Long interspersed nuclear element-1 (LINE-1 or L1) retrotransposons are normally suppressed in somatic tissues mainly due to DNA methylation and antiviral defense. However, the mechanism to suppress L1s may be disrupted in cancers, thus allowing… read more here.

Keywords: retrotransposition gastrointestinal; retrotransposition; expression; immune signatures ... See more keywords