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   Articles with "retrotransposition" as a keyword



Unraveling LINE-1 retrotransposition in head and neck squamous cell carcinoma.

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recommendations! Published in 2025 at "Molecular oncology"

DOI: 10.1002/1878-0261.70063

Abstract: The relevant role of LINE‐1 (L1) retrotransposition in cancer has been recurrently demonstrated in recent years. However, the repetitive nature of retrotransposons makes their identification and detection inaccessible for clinical practice. Also, its clinical relevance… read more here.

Keywords: neck squamous; head neck; activation; squamous cell ... See more keywords
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Heritable L1 Retrotransposition Events During Development: Understanding Their Origins

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recommendations! Published in 2018 at "Bioessays"

DOI: 10.1002/bies.201700189

Abstract: The retrotransposon Long Interspersed Element 1 (LINE‐1 or L1) has played a major role in shaping the sequence composition of the mammalian genome. In our recent publication, “Heritable L1 retrotransposition in the mouse primordial germline… read more here.

Keywords: retrotransposition events; events development; retrotransposition; heritable retrotransposition ... See more keywords

LINE‐1 vectors mediate recombinant antibody gene transfer by retrotransposition in Chinese hamster ovary cells

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recommendations! Published in 2021 at "Biotechnology Journal"

DOI: 10.1002/biot.202000620

Abstract: Retrotransposons, such as long interspersed element‐1 (LINE‐1), can copy themselves to other genomic loci via a transposition event (termed retrotransposition). Retrotransposons, therefore, have potential use as an efficient gene delivery tool to integrate multiple copies… read more here.

Keywords: vectors mediate; line; mediate recombinant; line vectors ... See more keywords

L1 retrotransposition alters the hippocampal genomic landscape enabling memory formation

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recommendations! Published in 2017 at "Brain, Behavior, and Immunity"

DOI: 10.1016/j.bbi.2016.12.018

Abstract: Somatic LINE-1 (L1) retrotransposition is a source of genomic mosaicism and potential phenotypic diversity among neurons during brain development. In the adult brain, L1 expression can be triggered by different environmental alterations, but its functional… read more here.

Keywords: memory formation; retrotransposition; alters hippocampal; retrotransposition alters ... See more keywords

Evaluating different DNA binding domains to modulate L1 ORF2p-driven site-specific retrotransposition events in human cells.

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recommendations! Published in 2018 at "Gene"

DOI: 10.1016/j.gene.2017.11.033

Abstract: DNA binding domains (DBDs) have been used with great success to impart targeting capabilities to a variety of proteins creating highly useful genomic tools. We evaluated the ability of five types of DBDs and strategies… read more here.

Keywords: binding domains; retrotransposition; orf2p driven; dna binding ... See more keywords
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Contribution of retrotransposition to developmental disorders

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recommendations! Published in 2019 at "Nature Communications"

DOI: 10.1038/s41467-019-12520-y

Abstract: Mobile genetic Elements (MEs) are segments of DNA which can copy themselves and other transcribed sequences through the process of retrotransposition (RT). In humans several disorders have been attributed to RT, but the role of… read more here.

Keywords: retrotransposition developmental; retrotransposition; contribution retrotransposition; developmental disorders ... See more keywords

Pan-cancer multi-omic model of LINE-1 activity reveals locus heterogeneity of retrotransposition efficiency

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-57271-1

Abstract: Somatic mobilization of LINE-1 (L1) has been implicated in cancer etiology. We analyzed a recent TCGA data release comprised of nearly 5000 pan-cancer paired tumor-normal whole-genome sequencing (WGS) samples and ~9000 tumor RNA samples. We… read more here.

Keywords: retrotransposition; cancer; pan cancer; line activity ... See more keywords

Opposing roles of pseudokinases NRBP1 and NRBP2 in regulating L1 retrotransposition

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-61626-z

Abstract: Gene duplication generates gene paralogs that may undergo diverse fates during evolution, and thus serves as a potent catalyst of biological complexity. Genetic paralogs frequently share redundant functions and may also exhibit antagonistic activities by… read more here.

Keywords: opposing roles; roles pseudokinases; nrbp1 nrbp2; gene duplication ... See more keywords
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Characterization of an active LINE-1 in the naked mole-rat genome

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recommendations! Published in 2021 at "Scientific Reports"

DOI: 10.1038/s41598-021-84962-8

Abstract: Naked mole-rats (NMRs, Heterocephalus glaber) are the longest-living rodent species. A reason for their long lifespan is pronounced cancer resistance. Therefore, researchers believe that NMRs have unknown secrets of cancer resistance and seek to find… read more here.

Keywords: nmr genome; cancer resistance; naked mole; retrotransposition ... See more keywords

The L1-ORF1p coiled coil enables formation of a tightly compacted nucleic acid-bound complex that is associated with retrotransposition

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recommendations! Published in 2022 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkac628

Abstract: Abstract Long interspersed nuclear element 1 (L1) parasitized most vertebrates and constitutes ∼20% of the human genome. It encodes ORF1p and ORF2p which form an L1-ribonucleoprotein (RNP) with their encoding transcript that is copied into… read more here.

Keywords: retrotransposition; coiled coil; tightly compacted; nucleic acid ... See more keywords

A novel role of TRIM28 B box domain in L1 retrotransposition and ORF2p-mediated cDNA synthesis

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recommendations! Published in 2023 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkad247

Abstract: Abstract The long interspersed element 1 (LINE-1 or L1) integration is affected by many cellular factors through various mechanisms. Some of these factors are required for L1 amplification, while others either suppress or enhance specific… read more here.

Keywords: box domain; retrotransposition; cdna synthesis; trim28 box ... See more keywords