Premature Stop Codon at Residue 101 within HIV-1 Rev Does Not Influence Viral Replication of Clade BC but Severely Reduces Viral Fitness of Clade B
Sign Up to like & getrecommendations! Published in 2019 at "Virologica Sinica"
DOI: 10.1007/s12250-019-00179-0
Abstract: HIV-1 Rev is an accessory protein that plays a key role in nuclear exportation, stabilization, and translation of the viral mRNAs. Rev of HIV-1 clade BC often shows a truncation of 16 AAs due to… read more here.
Keywords: premature stop; rev; clade; stop codon ... See more keywords
Rev‐erb regulation of cholesterologenesis
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DOI: 10.1016/j.bcp.2017.02.006
Abstract: ABSTRACT REV‐ERB&agr; and REV‐ERB&bgr; are heme regulated nuclear receptors that are known to regulate metabolic pathways. We previously demonstrated that treatment of mice with synthetic REV‐ERB agonists suppressed plasma cholesterol levels and the hepatic levels… read more here.
Keywords: rev erb; expression; rev; cholesterol levels ... See more keywords
Involvement of REV-ERBα dysregulation and ferroptosis in aristolochic acid I-induced renal injury.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2021.114807
Abstract: The molecular events underlying aristolochic acid (AA) nephropathy are poorly understood, and specific therapies for treatment of AA nephropathy are still lacking. Here we aimed to investigate a potential role of REV-ERBα and ferroptosis in… read more here.
Keywords: rev erb; ferroptosis; renal injury; rev ... See more keywords
O31 Evaluating Success of Paraprofessional Educators in a Pilot Adolescent Classroom Intervention: Rev It Up!
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Nutrition Education and Behavior"
DOI: 10.1016/j.jneb.2020.04.043
Abstract: Objective To evaluate Rev It Up!, a pilot nutrition education curriculum for teens, when it is taught by either paraprofessional or professional educators. Use of Theory or Research Research shows teens consume low levels of… read more here.
Keywords: intervention; nutrition education; rev; curriculum ... See more keywords
Development of Brucella melitensis Rev.1 ΔOmp19 mutants with DIVA feature and comparison of their efficacy against three commercial vaccines in a mouse model.
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DOI: 10.1016/j.molimm.2021.02.006
Abstract: Brucella is an intracellular zoonotic pathogen that can affect many hosts. Brucella melitensis Rev.1 is a live attenuated, is one of the most effective vaccine strain against brucellosis. It can be used safely in sheep,… read more here.
Keywords: brucella; rev; melitensis rev; commercial vaccines ... See more keywords
Development of a Novel Dual-Order Protein-Based Nanodelivery Carrier That Rapidly Targets Low-Grade Gliomas with Microscopic Metastasis in Vivo
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.0c03073
Abstract: Clinically diagnosing low-grade gliomas and microscopic metastatic tumors in the spinal cord using magnetic resonance imaging (MRI) is challenging, as the blood–brain barrier (BBB) almost completely excludes the MRI contrast agent gadopentetate dimeglumine, GdDTPA (Magnevist),… read more here.
Keywords: gliomas microscopic; rev; rev ang;
Nucleolar Localization of HIV-1 Rev Is Required, Yet Insufficient for Production of Infectious Viral Particles
Sign Up to like & getrecommendations! Published in 2018 at "AIDS Research and Human Retroviruses"
DOI: 10.1089/aid.2017.0306
Abstract: Abstract Combination antiretroviral therapy fails in complete suppression of HIV-1 due to drug resistance and persistent latency. Novel therapeutic intervention requires knowledge of intracellular pathways responsible for viral replication, specifically those untargeted by antiretroviral drugs.… read more here.
Keywords: production; rev; hiv; nucleolar localization ... See more keywords
Circadian nuclear receptor Rev-erbα is expressed by platelets and potentiates platelet activation and thrombus formation
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DOI: 10.1093/eurheartj/ehac109
Abstract: Abstract Aims Adverse cardiovascular events have day/night patterns with peaks in the morning, potentially related to endogenous circadian clock control of platelet activation. Circadian nuclear receptor Rev-erbα is an essential and negative component of the… read more here.
Keywords: rev; platelet activation; rev erb;
A Novel, Fully Spliced, Accessory Gene in Equine Lentivirus with Distinct Rev-Responsive Element
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DOI: 10.1128/jvi.00986-22
Abstract: In lentiviruses, the nuclear export of viral transcripts is an important step in controlling viral gene expression. Generally, the unspliced and incompletely spliced transcripts are exported via the CRM1-dependent export pathway in a process mediated… read more here.
Keywords: fully spliced; responsive element; rev responsive; nuclear export ... See more keywords
Vaccine Candidate Brucella melitensis 16MΔvjbR Is Safe in a Pregnant Sheep Model and Confers Protection
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DOI: 10.1128/msphere.00120-20
Abstract: Brucellosis is one of the most commonly reported zoonotic disease with a worldwide distribution. Of the 12 Brucella species, Brucella melitensis is considered the most virulent and causes reproductive failure (abortions/stillbirths) in small ruminants, which… read more here.
Keywords: rev; 16m vjbr; brucella melitensis; melitensis ... See more keywords
Transcriptional repression of the MRTF/SRF-cytoskeleton pathway by Rev-erba promotes beigeing via adipogenic progenitor fate switch
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733080
Abstract: The circadian clock exerts temporal control in metabolic processes to maintain homeostasis, with its disruption leading to the development of obesity and insulin resistance. Adipose fibrosis in obese subjects exacerbates insulin resistance by restricting healthy… read more here.
Keywords: mrtf srf; fate; physiology; rev erb ... See more keywords