Reverse Erythroblastosis Virus α Antagonism Promotes Homocysteine Catabolism and Ammonia Clearance
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30675
Abstract: Metabolic homeostasis of amino acids is essential for human health. Here, we aimed to investigate a potential role for the clock component reverse erythroblastosis virus α (Rev‐erbα) in circadian regulation of amino acid metabolism. RNA‐seq… read more here.
Keywords: rev erb; ammonia clearance; erb; antagonism ... See more keywords
Binding mode prediction and MD/MMPBSA-based free energy ranking for agonists of REV-ERBα/NCoR
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Computer-Aided Molecular Design"
DOI: 10.1007/s10822-017-0040-7
Abstract: The knowledge of the free energy of binding of small molecules to a macromolecular target is crucial in drug design as is the ability to predict the functional consequences of binding. We highlight how a… read more here.
Keywords: mode prediction; ncor; rev erb; binding mode ... See more keywords
Rev-erbα regulates hepatic ischemia-reperfusion injury in mice.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.06.152
Abstract: Hepatic ischemia-reperfusion (I/R) injury is a complex pathophysiological process that often times occurs in liver transplantation, hepatectomy, and ischemic shock. Aberrant activation of inflammatory responses has been implicated in hepatic I/R injury. In this study,… read more here.
Keywords: rev erb; injury; hepatic injury; mice ... See more keywords
Rev‐erb regulation of cholesterologenesis
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2017.02.006
Abstract: ABSTRACT REV‐ERB&agr; and REV‐ERB&bgr; are heme regulated nuclear receptors that are known to regulate metabolic pathways. We previously demonstrated that treatment of mice with synthetic REV‐ERB agonists suppressed plasma cholesterol levels and the hepatic levels… read more here.
Keywords: rev erb; expression; rev; cholesterol levels ... See more keywords
The nuclear receptor Rev‐erb&agr; participates in circadian regulation of Ugt2b enzymes in mice
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2019.01.010
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT Circadian clock is known to modulate phase I metabolism, however whether and how the phase II enzymes UDP‐glucuronosyltransferases (UGTs) are regulated by circadian clock are largely unknown. In… read more here.
Keywords: rev erb; regulation ugt2b; erb agr;
Involvement of REV-ERBα dysregulation and ferroptosis in aristolochic acid I-induced renal injury.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2021.114807
Abstract: The molecular events underlying aristolochic acid (AA) nephropathy are poorly understood, and specific therapies for treatment of AA nephropathy are still lacking. Here we aimed to investigate a potential role of REV-ERBα and ferroptosis in… read more here.
Keywords: rev erb; ferroptosis; renal injury; rev ... See more keywords
Inhibition of Rev-erbα Ameliorates Muscular Dystrophy.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2021.112766
Abstract: Duchene muscular dystrophy leads to progressive muscle structural and functional decline due to chronic degenerative-regenerative cycles. Enhancing the regenerative capacity of dystrophic muscle provides potential therapeutic options. We previously demonstrated that the circadian clock repressor… read more here.
Keywords: rev erb; muscle; muscular dystrophy;
Pharmacological activation of REV-ERBα represses LPS-induced microglial activation through the NF-κB pathway
Sign Up to like & getrecommendations! Published in 2018 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-018-0064-0
Abstract: REV-ERBα, the NR1D1 (nuclear receptor subfamily 1, group D, member 1) gene product, is a dominant transcriptional silencer that represses the expression of genes involved in numerous physiological functions, including circadian rhythm, inflammation, and metabolism,… read more here.
Keywords: rev erb; lps induced; activation; microglial activation ... See more keywords
Muscle circadian clock regulates lipid storage
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Endocrinology"
DOI: 10.1038/s41574-018-0089-y
Abstract: Brain and muscle ARNT-like protein 1 (BMAL1, also known as ARNTL) together with other clock proteins regulates the body’s circadian rhythm, which controls energy homeostasis. The muscle clock regulates insulin sensitivity and glucose metabolism; however,… read more here.
Keywords: bmal1; muscle; rev erb; mice ... See more keywords
Rev-erb-α regulates atrophy-related genes to control skeletal muscle mass
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-14596-2
Abstract: The nuclear receptor Rev-erb-α modulates hepatic lipid and glucose metabolism, adipogenesis and thermogenesis. We have previously demonstrated that Rev-erb-α is also an important regulator of skeletal muscle mitochondrial biogenesis and function, and autophagy. As such,… read more here.
Keywords: rev erb; muscle; muscle mass; skeletal muscle ... See more keywords
Pharmacological inhibition of REV-ERB stimulates differentiation, inhibits turnover and reduces fibrosis in dystrophic muscle
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-17496-7
Abstract: Duchenne muscular dystrophy (DMD) is a debilitating X-linked disorder that is fatal. DMD patients lack the expression of the structural protein dystrophin caused by mutations within the DMD gene. The absence of functional dystrophin protein… read more here.
Keywords: rev erb; muscle; differentiation; pharmacological inhibition ... See more keywords