Development and Validation of an Abridged Version of the REVEAL 2.0 Risk Score Calculator, REVEAL Lite 2, for Use in Patients With Pulmonary Arterial Hypertension
Sign Up to like & getrecommendations! Published in 2020 at "Chest"
DOI: 10.1016/j.chest.2020.08.2069
Abstract: Background Achievement of low-risk status is a treatment goal in pulmonary arterial hypertension (PAH). Risk assessment is often performed using multiparameter tools, such as the Registry to Evaluate Early and Long-term PAH Disease Management (REVEAL)… read more here.
Keywords: risk; reveal risk; reveal lite; reveal ... See more keywords
Structures of the Human PGD2 Receptor CRTH2 Reveal Novel Mechanisms for Ligand Recognition.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.08.009
Abstract: The signaling of prostaglandin D2 (PGD2) through G-protein-coupled receptor (GPCR) CRTH2 is a major pathway in type 2 inflammation. Compelling evidence suggests the therapeutic benefits of blocking CRTH2 signaling in many inflammatory disorders. Currently, a… read more here.
Keywords: crth2; recognition; structures human; reveal ... See more keywords
Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy
Sign Up to like & getrecommendations! Published in 2019 at "Cell Stem Cell"
DOI: 10.1016/j.stem.2019.10.005
Abstract: Summary Medulloblastoma (MB), the most frequent malignant childhood brain tumor, can arise from cellular malfunctions during hindbrain development. Here we generate humanized models for Sonic Hedgehog (SHH)-subgroup MB via MYCN overexpression in primary human hindbrain-derived… read more here.
Keywords: oct4; stem cell; mtor; reveal ... See more keywords
Warthog Genomes Resolve an Evolutionary Conundrum and Reveal Introgression of Disease Resistance Genes
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msac134
Abstract: Abstract African wild pigs have a contentious evolutionary and biogeographic history. Until recently, desert warthog (Phacochoerus aethiopicus) and common warthog (P. africanus) were considered a single species. Molecular evidence surprisingly suggested they diverged at least… read more here.
Keywords: reveal; introgression; warthog; range ... See more keywords
Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1207
Abstract: The SARS-CoV-2 non-structural protein 14 (NSP14) is a dual function enzyme containing an N-terminal exonuclease domain (ExoN) and C-terminal Guanine-N7-methyltransferase (N7-MTase) domain. Both enzymatic activities appear to be essential for the viral life cycle and… read more here.
Keywords: reveal; structure; mrna capping; fragment screening ... See more keywords
Haptophyte communities along the Kuroshio current reveal their geographical sources and ecological traits
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Ecology"
DOI: 10.1111/mec.16734
Abstract: Haptophytes are one of the most ecologically successful phytoplankton groups in the modern ocean and tend to maintain balanced and stable communities across various environments. However, little is known about the mechanisms that enable community… read more here.
Keywords: reveal; haptophyte communities; community; along kuroshio ... See more keywords
Already high tobacco taxes are still a burden on low-income households
Sign Up to like & getrecommendations! Published in 2020 at "Tobacco Control"
DOI: 10.1136/tobaccocontrol-2020-055734
Abstract: The French Pulmonary Hypertension Network (FPHN) registry and the Registry to Evaluate Early And Long-term Pulmonary Arterial Hypertension Disease Management (REVEAL) have developed predictive models for survival in pulmonary arterial hypertension (PAH). In this collaboration,… read more here.
Keywords: tobacco; reveal risk; high tobacco; already high ... See more keywords
Plasma Cell-Free DNA Predicts Survival and Maps Specific Sources of Injury in Pulmonary Arterial Hypertension
Sign Up to like & getrecommendations! Published in 2022 at "Circulation"
DOI: 10.1161/circulationaha.121.056719
Abstract: Background: Cell-free DNA (cfDNA) is a noninvasive marker of cellular injury. Its significance in pulmonary arterial hypertension (PAH) is unknown. Methods: Plasma cfDNA was measured in 2 PAH cohorts (A, n=48; B, n=161) and controls… read more here.
Keywords: reveal; patients pah; cell free; cfdna ... See more keywords
Quantification of aortic stenosis diagnostic parameters: comparison of fast 3 direction and 1 direction phase contrast CMR and transthoracic echocardiography
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cardiovascular Magnetic Resonance"
DOI: 10.1186/s12968-017-0339-5
Abstract: BackgroundAortic stenosis (AS) is a common valvular disorder, and disease severity is currently assessed by transthoracic echocardiography (TTE). However, TTE results can be inconsistent in some patients, thus other diagnostic modalities such as cardiovascular magnetic… read more here.
Keywords: direction; 1dir cmr; 3dir cmr; tte ... See more keywords
All-Atom MD Simulations of the HBV Capsid Complexed with AT130 Reveal Secondary and Tertiary Structural Changes and Mechanisms of Allostery
Sign Up to like & getrecommendations! Published in 2021 at "Viruses"
DOI: 10.3390/v13040564
Abstract: The hepatitis B virus (HBV) capsid is an attractive drug target, relevant to combating viral hepatitis as a major public health concern. Among small molecules known to interfere with capsid assembly, the phenylpropenamides, including AT130,… read more here.
Keywords: simulations hbv; hbv capsid; atom simulations; reveal ... See more keywords
Baseline Demographics, Safety, and Patient Acceptance of an Insertable Cardiac Monitor for Atrial Fibrillation Screening: The REVEAL-AF Study.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of atrial fibrillation"
DOI: 10.4022/jafib.1551
Abstract: Given the high prevalence and risk of stroke associated with atrial fibrillation (AF), detection strategies have important public health implications. The ongoing prospective, single-arm, open-label, multicenter REVEAL AF trial is evaluating the incidence of previously… read more here.
Keywords: atrial fibrillation; risk; insertable cardiac; reveal ... See more keywords