What voltage-sensing phosphatases can reveal about the mechanisms of ion channel regulation by phosphoinositides.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemical Society transactions"
DOI: 10.1042/bst20221065
Abstract: Many membrane proteins including ion channels and ion transporters are regulated by membrane phospholipids such as phosphoinositides in cell membranes and organelles. Voltage-sensing phosphatase, VSP, is a voltage-sensitive phosphoinositide phosphatase which dephosphorylates PI(4,5)P2 into PI(4)P.… read more here.
Keywords: voltage sensing; phosphatases reveal; regulation; reveal mechanisms ... See more keywords
Modulating environmental signals to reveal mechanisms and vulnerabilities of cancer persisters
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DOI: 10.1126/sciadv.abi7711
Abstract: Cancer persister cells are able to survive otherwise lethal doses of drugs through nongenetic mechanisms, which can lead to cancer regrowth and drug resistance. The broad spectrum of molecular differences observed between persisters and their… read more here.
Keywords: persistence; environmental signals; modulating environmental; signals reveal ... See more keywords
Spatial metabolomics reveal mechanisms of dexamethasone against pediatric pneumonia.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.2139/ssrn.4369317
Abstract: Currently, drugs are limited to treating pediatric pneumonia in clinical practice. It is urgent to find one new precise prevention and control therapy. The dynamically changing biomarkers during the development of pediatric pneumonia could help… read more here.
Keywords: pneumonia; pediatric pneumonia; reveal mechanisms; metabolomics reveal ... See more keywords