Thermodynamic Analysis of Tyrosyl-tRNA Synthetases Revealed Bacterial-Selective Tyrosine Derivatives
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DOI: 10.1071/ch21218
Abstract: The non-proteinogenic amino acids m-fluorotyrosine and 2,4-dihydroxyphenylalanine demonstrated a respective 6- and 12-fold greater binding affinity to the purified tyrosyl-tRNA synthetase from Escherichia coli than that from human cytosol. The differential binding was identified by… read more here.
Keywords: thermodynamic analysis; synthetases revealed; analysis tyrosyl; revealed bacterial ... See more keywords