Dynamic Structural Modeling Revealed That Nilotinib Inhibits Smoothened Signaling
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DOI: 10.1093/neuros/nyz310_806
Abstract: Dysregulation of the 7-transmembrane receptors Smoothened (SMO) and other components of the Hedgehog (Hh) signaling pathway causes several cancers, including medulloblastoma (MB) and glioblastoma. However, SMO-specific antagonists produced mixed results in clinical trials, marked by… read more here.
Keywords: dynamic structural; revealed nilotinib; nilotinib inhibits; modeling revealed ... See more keywords