Pangenomics reveals alternative environmental lifestyles among chlamydiae
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24294-3
Abstract: Chlamydiae are highly successful strictly intracellular bacteria associated with diverse eukaryotic hosts. Here we analyzed metagenome-assembled genomes of the “Genomes from Earth’s Microbiomes” initiative from diverse environmental samples, which almost double the known phylogenetic diversity… read more here.
Keywords: lifestyles among; chlamydiae; pangenomics reveals; alternative environmental ... See more keywords
Mathematical modeling reveals alternative JAK inhibitor treatment in myeloproliferative neoplasms
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DOI: 10.3324/haematol.2018.203729
Abstract: The identification of JAK-STAT pathway mutations in the majority of patients with myeloproliferative neoplasms (MPN) led to the clinical development of JAK inhibitors and resulted in the approval of ruxolitinib for MPN therapy. Despite this… read more here.
Keywords: jak inhibitor; mathematical modeling; alternative jak; modeling reveals ... See more keywords
Untargeted NMR Metabolomics Reveals Alternative Biomarkers and Pathways in Alkaptonuria
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232415805
Abstract: Alkaptonuria (AKU) is an ultra-rare metabolic disease caused by the accumulation of homogentisic acid (HGA), an intermediate product of phenylalanine and tyrosine degradation. AKU patients carry variants within the gene coding for homogentisate-1,2-dioxygenase (HGD), which… read more here.
Keywords: biomarkers pathways; untargeted nmr; alternative biomarkers; reveals alternative ... See more keywords