NMR Reveals Functionally Relevant Thermally Induced Structural Changes within the Native Ensemble of G-CSF
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00398
Abstract: Structure–function relationships in proteins refer to a trade-off between stability and bioactivity, molded by evolution of the molecule. Identifying which protein amino acid residues jeopardize global or local stability for the benefit of bioactivity would… read more here.
Keywords: csf; reveals functionally; relevant thermally; functionally relevant ... See more keywords
Single-cell transcriptomics reveals functionally specialized vascular endothelium in brain
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.06.10.495613
Abstract: The blood-brain barrier (BBB) limits the entry of leukocytes and potentially harmful substances from the circulation into the central nervous system (CNS). While BBB defects are a hallmark of many neurological disorders, the cellular heterogeneity… read more here.
Keywords: cell; cell transcriptomics; brain; reveals functionally ... See more keywords
Intrinsic connectivity reveals functionally distinct cortico-hippocampal networks in the human brain
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Biology"
DOI: 10.1371/journal.pbio.3001275
Abstract: Episodic memory depends on interactions between the hippocampus and interconnected neocortical regions. Here, using data-driven analyses of resting-state functional magnetic resonance imaging (fMRI) data, we identified the networks that interact with the hippocampus—the default mode… read more here.
Keywords: connectivity reveals; connectivity; subnetwork comprised; functionally distinct ... See more keywords