Epigenetic profiling reveals key genes and cis-regulatory networks specific to human parathyroids
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-46181-3
Abstract: In all terrestrial vertebrates, the parathyroid glands are critical regulators of calcium homeostasis and the sole source of parathyroid hormone (PTH). Hyperparathyroidism and hypoparathyroidism are clinically important disorders affecting multiple organs. However, our knowledge regarding… read more here.
Keywords: human parathyroids; reveals key; parathyroid glands; parathyroid ... See more keywords
Integrative modeling reveals key chromatin and sequence signatures predicting super-enhancers
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-38979-9
Abstract: Super-enhancers (SEs) are clusters of transcriptional enhancers which control the expression of cell identity and disease-associated genes. Current studies demonstrated the role of multiple factors in SE formation; however, a systematic analysis to assess the… read more here.
Keywords: chromatin sequence; integrative modeling; reveals key; modeling reveals ... See more keywords
Characterization of SrUGT76G4 reveals a key residue for regioselectivity and efficient Reb M synthesis.
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2504698122
Abstract: Steviol glycosides (SGs) from Stevia rebaudiana are prized as noncaloric sweeteners, with rebaudioside M (Reb M)-a next-generation SG known for its sucrose-like sweetness and lack of off-tastes-standing out for its superior sensory profile. However, Reb… read more here.
Keywords: regioselectivity; reveals key; srugt76g4 reveals; reb ... See more keywords
Comparative population genomics reveals key barriers to dispersal in Southern Ocean penguins
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Ecology"
DOI: 10.1111/mec.14896
Abstract: The mechanisms that determine patterns of species dispersal are important factors in the production and maintenance of biodiversity. Understanding these mechanisms helps to forecast the responses of species to environmental change. Here, we used a… read more here.
Keywords: comparative population; reveals key; oceanography; population genomics ... See more keywords
Machine learning reveals key ion selectivity mechanisms in polymeric membranes with subnanometer pores
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abl5771
Abstract: Machine learning unveils molecular transport mechanisms obscured by entropy-enthalpy compensation in polymeric membranes. read more here.
Keywords: learning reveals; polymeric membranes; reveals key; machine learning ... See more keywords
The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Research"
DOI: 10.1158/0008-5472.can-22-0446
Abstract: Transcriptomic analysis reveals a key role for the PI3K pathway in regulating RNA splicing, uncovering new mechanisms by which PI3K regulates proliferation and metabolism in breast cancer. read more here.
Keywords: pi3k; reveals key; induced transcriptomic; pi3k induced ... See more keywords