Incomplete Trisomy Rescue Reveals the Mechanism Underlying Discordance Between Noninvasive Prenatal Screening and Prenatal Diagnosis
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.70091
Abstract: Uniparental disomy (UPD) is a specific type of chromosomal variation in which both chromosomes of a homologous pair are inherited from the same parent. It is responsible for a wide range of disorders. Monosomy rescue… read more here.
Keywords: incomplete trisomy; rescue reveals; trisomy rescue; trisomy ... See more keywords
Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abq6353
Abstract: Repair of DNA damage is critical to genomic integrity and frequently disrupted in cancers. USP1, a nucleus-localized deubiquitinase, lies at the interface of multiple DNA repair pathways and is a promising drug target for certain… read more here.
Keywords: binding; inhibition; reveals mechanism; cryo reveals ... See more keywords
Metabolomics reveals the mechanism of polyethylene microplastic toxicity to Daphnia magna.
Sign Up to like & getrecommendations! Published in 2022 at "Chemosphere"
DOI: 10.2139/ssrn.4126738
Abstract: Microplastic exposure leads to various toxic effects in Daphnia magna; however, the effects of microplastics on the metabolic processes in D. magna and the corresponding molecular toxicity mechanisms remain unclear. In the present study, the… read more here.
Keywords: mps mps; metabolomics reveals; toxicity; reveals mechanism ... See more keywords