Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abq6353
Abstract: Repair of DNA damage is critical to genomic integrity and frequently disrupted in cancers. USP1, a nucleus-localized deubiquitinase, lies at the interface of multiple DNA repair pathways and is a promising drug target for certain… read more here.
Keywords: binding; inhibition; reveals mechanism; cryo reveals ... See more keywords
Metabolomics reveals the mechanism of polyethylene microplastic toxicity to Daphnia magna.
Sign Up to like & getrecommendations! Published in 2022 at "Chemosphere"
DOI: 10.2139/ssrn.4126738
Abstract: Microplastic exposure leads to various toxic effects in Daphnia magna; however, the effects of microplastics on the metabolic processes in D. magna and the corresponding molecular toxicity mechanisms remain unclear. In the present study, the… read more here.
Keywords: mps mps; metabolomics reveals; toxicity; reveals mechanism ... See more keywords