Cryo-EM reveals mechanistic insights into lipid-facilitated polyamine export by human ATP13A2.
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DOI: 10.1016/j.molcel.2021.11.001
Abstract: The cytoplasmic polyamine maintains cellular homeostasis by chelating toxic metal cations, regulating transcriptional activity, and protecting DNA. ATP13A2 was identified as a lysosomal polyamine exporter responsible for polyamine release into the cytosol, and its dysfunction… read more here.
Keywords: reveals mechanistic; human atp13a2; polyamine; cryo reveals ... See more keywords