Ultrastructural Analysis Reveals Mitochondrial Placement Independent of Synapse Placement in Fine Caliber C. elegans Neurons
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.70002
Abstract: Neurons rely on mitochondria for an efficient supply of ATP and other metabolites. However, while neurons are highly elongated, mitochondria are discrete and limited in number. Due to the slow rates of metabolite diffusion over… read more here.
Keywords: reveals mitochondrial; placement; synaptic varicosities; fine caliber ... See more keywords
In situ fluorescence imaging reveals that mitochondrial H2O2 mediates lysosomal dysfunction in depression.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc00431c
Abstract: We constructed two fluorescent probes for monitoring H2O2 in the mitochondria and lysosomes. Fluorescence imaging reveals that mitochondrial H2O2 mediates reduced GCase activity in lysosomes in the brains of mice with depression. This work provides… read more here.
Keywords: reveals mitochondrial; depression; fluorescence imaging; mitochondrial h2o2 ... See more keywords