Drug repositioning in epilepsy reveals novel antiseizure candidates
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.703
Abstract: Epilepsy treatment falls short in ~30% of cases. A better understanding of epilepsy pathophysiology can guide rational drug development in this difficult to treat condition. We tested a low‐cost, drug‐repositioning strategy to identify candidate epilepsy… read more here.
Keywords: epilepsy; drug repositioning; epilepsy reveals; reveals novel ... See more keywords
Quantitative phosphoproteomics reveals novel roles of cAMP in plants.
Sign Up to like & getrecommendations! Published in 2023 at "Proteomics"
DOI: 10.1002/pmic.202300165
Abstract: 3',5'-cyclic adenosine monophosphate (cAMP) is finally recognized as an essential signaling molecule in plants where cAMP-dependent processes include responses to hormones and environmental stimuli. To better understand the role of 3',5'-cAMP at the systems level,… read more here.
Keywords: quantitative phosphoproteomics; reveals novel; novel roles; camp ... See more keywords
A Multifaceted Hit-Finding Approach Reveals Novel LC3 Family Ligands.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.1c00682
Abstract: Autophagy-related proteins (Atgs) drive the lysosome-mediated degradation pathway, autophagy, to enable the clearance of dysfunctional cellular components and maintain homeostasis. In humans, this process is driven by the mammalian Atg8 (mAtg8) family of proteins comprising… read more here.
Keywords: reveals novel; multifaceted hit; family; approach reveals ... See more keywords
Erratum: GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Psychiatry"
DOI: 10.1038/mp.2017.197
Abstract: This corrects the article DOI: dx.doi.org/10.1038 read more here.
Keywords: analysis reveals; gwas meta; reveals novel; erratum gwas ... See more keywords
Proteome profiling reveals novel biomarkers to identify complicated parapneumonic effusions
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-04189-4
Abstract: Patients with pneumonia and parapneumonic effusion (PPE) have elevated mortality and a poor prognosis. The aim of this study was to discover novel biomarkers to help distinguish between uncomplicated PPE (UPPE) and complicated PPE (CPPE).… read more here.
Keywords: reveals novel; profiling reveals; identify complicated; biomarkers identify ... See more keywords
Exome Sequencing Reveals Novel TTN Variants in Saudi Patients with Congenital Titinopathies.
Sign Up to like & getrecommendations! Published in 2021 at "Genetic testing and molecular biomarkers"
DOI: 10.1089/gtmb.2021.0085
Abstract: Aim: Our goal was to determine the genetic basis of early-onset myopathy in patients from two unrelated families. Materials and Methods: Whole-exome sequencing, autozygosity mapping, and confirmatory targeted Sanger sequencing were performed using genomic DNA… read more here.
Keywords: year old; variant; reveals novel; sequencing reveals ... See more keywords
MaLAdapt Reveals Novel Targets of Adaptive Introgression From Neanderthals and Denisovans in Worldwide Human Populations
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msad001
Abstract: Adaptive introgression (AI) facilitates local adaptation in a wide range of species. Many state-of-the-art methods detect AI with ad-hoc approaches that identify summary statistic outliers or intersect scans for positive selection with scans for introgressed… read more here.
Keywords: reveals novel; introgression; maladapt reveals; adaptive introgression ... See more keywords
Genetic analysis reveals novel variants for vascular cognitive impairment
Sign Up to like & getrecommendations! Published in 2022 at "Acta Neurologica Scandinavica"
DOI: 10.1111/ane.13613
Abstract: The genetic background of vascular cognitive impairment (VCI) is poorly understood compared to other dementia disorders. The aim of the study was to investigate the genetic background of VCI in a well‐characterized Finnish cohort. read more here.
Keywords: reveals novel; vascular cognitive; cognitive impairment; genetic analysis ... See more keywords
Multidimensional flow cytometry reveals novel platelet subpopulations in response to prostacyclin
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15330
Abstract: Robust platelet activation leads to the generation of subpopulations characterized by differential expression of phosphatidylserine (PS). Prostacyclin (PGI2) modulates many aspects of platelet function, but its influence on platelet subpopulations is unknown. read more here.
Keywords: reveals novel; platelet subpopulations; multidimensional flow; cytometry reveals ... See more keywords
Next generation sequencing reveals a novel HLA‐C allele, HLA‐C*16:201
Sign Up to like & getrecommendations! Published in 2023 at "HLA"
DOI: 10.1111/tan.14979
Abstract: HLA‐C*16:201 differs from HLA‐HLA‐C*16:01:01 by one nucleotide substitution in codon 73 (ACT ‐>GCT). read more here.
Keywords: reveals novel; hla; sequencing reveals; hla 201 ... See more keywords
Next-generation sequencing reveals a novel HLA-C allele, HLA-C*15:255.
Sign Up to like & getrecommendations! Published in 2023 at "HLA"
DOI: 10.1111/tan.15038
Abstract: HLA-C*15:255 differs from HLA-C*15:02:01 by five nucleotide substitutions located in exons 4 and 5. read more here.
Keywords: reveals novel; hla; hla 255; sequencing reveals ... See more keywords