Large-Scale Phosphoproteomics Reveals Shp-2 Phosphatase-Dependent Regulators of Pdgf Receptor Signaling.
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DOI: 10.1016/j.celrep.2018.02.038
Abstract: Despite its low cellular abundance, phosphotyrosine (pTyr) regulates numerous cell signaling pathways in health and disease. We applied comprehensive phosphoproteomics to unravel differential regulators of receptor tyrosine kinase (RTK)-initiated signaling networks upon activation by Pdgf-ββ, Fgf-2,… read more here.
Keywords: large scale; phosphatase dependent; phosphoproteomics reveals; shp phosphatase ... See more keywords