Anticoagulant Reversal in Gastrointestinal Bleeding: Review of Treatment Guidelines
Sign Up to like & getrecommendations! Published in 2021 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-020-06728-y
Abstract: Patients receiving anticoagulant therapies, such as vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs), commonly experience gastrointestinal (GI) bleeding as a complication and may require anticoagulant reversal prior to endoscopic treatment. Anticoagulant reversal agents… read more here.
Keywords: reversal; reversal agents; gastrointestinal bleeding; review ... See more keywords
Design, synthesis and bioactivity study on 5-phenylfuran derivatives as potent reversal agents against P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113336
Abstract: P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is a phenomenon in which cells become resistant to structurally and mechanistically unrelated drugs resulting in low intracellular drug concentrations. It is one of the noteworthy problems in malignant tumor… read more here.
Keywords: mediated multidrug; reversal agents; mcf adr; glycoprotein mediated ... See more keywords
Antithrombotic Reversal Agents.
Sign Up to like & getrecommendations! Published in 2017 at "Hematology/oncology clinics of North America"
DOI: 10.1016/j.hoc.2017.08.013
Abstract: The actively bleeding anticoagulated patient presenting to the emergency department requires rapid evaluation and treatment, which is made increasingly complicated by the ever-evolving antithrombotic treatment options used in medicine. Even with excellent supportive care, the… read more here.
Keywords: reversal; antithrombotic reversal; reversal agents;
Direct oral anticoagulants and the management of bleeding
Sign Up to like & getrecommendations! Published in 2021 at "Medicine"
DOI: 10.1016/j.mpmed.2020.12.003
Abstract: Abstract Over the past decade direct oral anticoagulants (DOACs) have become an increasingly popular choice in the treatment and prevention of venous and arterial thromboembolism, owing to the convenience of fixed dosing. Large Phase III… read more here.
Keywords: oral anticoagulants; direct oral; anticoagulants management; management bleeding ... See more keywords
Opioid Antagonists from the Orvinol Series as Potential Reversal Agents for Opioid Overdose
Sign Up to like & getrecommendations! Published in 2022 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.2c00464
Abstract: The opioid crisis continues to claim many lives, with a particular issue being the ready availability and use (whether intentional or accidental) of fentanyl and fentanyl analogues. Fentanyl is both potent and longer-acting than naloxone,… read more here.
Keywords: antagonists orvinol; series; reversal; opioid antagonists ... See more keywords
Screening Multidrug Resistance Reversal Agents in Traditional Chinese Medicines by Efflux Kinetics of D-Luciferin in MCF-7/DOXFluc Cells
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c07096
Abstract: In this study, we established a simple and rapid in vitro method for screening multidrug resistance (MDR) reversal agents in traditional Chinese medicines (TCMs), which could better correspond to the MDR reversing effect in vivo.… read more here.
Keywords: reversal agents; screening multidrug; mcf doxfluc; doxfluc ... See more keywords
Novel Quinoline Compound Derivatives of NSC23925 as Potent Reversal Agents Against P-Glycoprotein-Mediated Multidrug Resistance
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2019.00820
Abstract: Multidrug resistance is a serious problem and a common cause of cancer treatment failure, leading to patient death. Although numerous reversal resistance inhibitors have been evaluated in preclinical or clinical trials, efficient and low-toxicity reversal… read more here.
Keywords: quinoline compound; reversal agents; novel quinoline; resistance ... See more keywords
How I manage patients with anticoagulation-associated bleeding or urgent surgery.
Sign Up to like & getrecommendations! Published in 2018 at "Swiss medical weekly"
DOI: 10.4414/smw.2018.14598
Abstract: Antithrombotic treatment puts patients at risk of major bleeding. Fast and adequate response to anticoagulant-associated bleeding may not only stop the bleeding but prevent severe complications. However, practical treatment algorithms to guide physicians in emergency… read more here.
Keywords: surgery; bleeding urgent; reversal agents; manage patients ... See more keywords
Residual neuromuscular block in the postanesthesia care unit: incidence, risk factors, and effect of neuromuscular monitoring and reversal agents.
Sign Up to like & getrecommendations! Published in 2022 at "Turkish journal of medical sciences"
DOI: 10.55730/1300-0144.5507
Abstract: BACKGROUND The aim of this study was to determine the incidence of residual neuromuscular block (RNMB) in a tertiary care hospital. Secondary goals were to examine the characteristics of the use of intraoperative neuromuscular monitoring… read more here.
Keywords: incidence; neuromuscular block; care; reversal ... See more keywords