Clofazimine pKa Determination by Potentiometry and Spectrophotometry: Reverse Cosolvent Dependence as an Indicator of the Presence of Dimers in Aqueous Solutions.
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DOI: 10.1021/acs.molpharmaceut.3c00172
Abstract: The weakly basic antibiotic and anti-inflammatory drug, clofazimine (CFZ), was first described in 1957. It has been used therapeutically, most notably in the treatment of leprosy. However, the compound is extremely insoluble in aqueous media,… read more here.
Keywords: cfz; cosolvent dependence; pka; reverse cosolvent ... See more keywords