Prime editor with rational design and AI-driven optimization for reverse editing window and enhanced fidelity
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DOI: 10.1038/s41467-025-60495-w
Abstract: Prime editing (PE) is a precise tool for introducing genetic mutations in eukaryotes. Extending the efficient editing scope and mitigating undesired byproducts are possible. We introduce reverse PE (rPE), a SpCas9-directed variant that enabled DNA… read more here.
Keywords: reverse editing; rpe; window; fidelity ... See more keywords