Mitochondrial NADH redox potential impacts the reactive oxygen species production of reverse Electron transfer through complex I
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Bioenergetics and Biomembranes"
DOI: 10.1007/s10863-018-9767-7
Abstract: There is substantial evidence that Reactive Oxygen Species (ROS) play a major part in cell functioning. Although their harmfulness through oxidative stress is well documented, their role in signaling and sensing as an oxidative signal… read more here.
Keywords: electron transfer; ros production; reverse electron; production ... See more keywords
Acid enhancement of ROS generation by complex-I reverse electron transport is balanced by acid inhibition of complex-II: Relevance for tissue reperfusion injury
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DOI: 10.1016/j.redox.2020.101733
Abstract: Generation of mitochondrial reactive oxygen species (ROS) is an important process in triggering cellular necrosis and tissue infarction during ischemia-reperfusion (IR) injury. Ischemia results in accumulation of the metabolite succinate. Rapid oxidation of this succinate… read more here.
Keywords: electron transport; reperfusion; generation; reperfusion injury ... See more keywords
Reverse Electron Transfer by Respiratory Complex I Catalyzed in a Modular Proteoliposome System
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DOI: 10.1021/jacs.2c00274
Abstract: Respiratory complex I is an essential metabolic enzyme that uses the energy from NADH oxidation and ubiquinone reduction to translocate protons across an energy transducing membrane and generate the proton motive force for ATP synthesis.… read more here.
Keywords: system; respiratory complex; proteoliposome system; electron transfer ... See more keywords
Reverse electron transfer is activated during aging and contributes to aging and age‐related disease
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DOI: 10.15252/embr.202255548
Abstract: Mechanisms underlying the depletion of NAD+ and accumulation of reactive oxygen species (ROS) in aging and age‐related disorders remain poorly defined. We show that reverse electron transfer (RET) at mitochondrial complex I, which causes increased… read more here.
Keywords: age related; electron transfer; aging age; reverse electron ... See more keywords