Construction of carrier-free porphyrin-based drug self-framed delivery system to reverse multidrug resistance through photodynamic-chemotherapy
Sign Up to like & getrecommendations! Published in 2020 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2019.107922
Abstract: Abstract For clinical application, it is still giant challenge to reverse multidrug resistance. High efficiency, low toxicity and simplicity are key issues to design nanomedicines. Herein, we fabricated porphyrin-based drug self-framed delivery systems without any… read more here.
Keywords: drug; reverse multidrug; delivery; multidrug resistance ... See more keywords
Simplified Derivatives of Tetrandrine as Potent and Specific P-gp Inhibitors to Reverse Multidrug Resistance in Cancer Chemotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c02061
Abstract: Targeted inhibition of a drug efflux transporter P-glycoprotein (P-gp) is an important strategy to reverse multidrug resistance in cancer chemotherapy. In this study, a rationally structural simplification to natural tetrandrine was performed based on molecular… read more here.
Keywords: resistance cancer; multidrug resistance; reverse multidrug; cancer chemotherapy ... See more keywords