Intramembranous processing by γ‐secretase regulates reverse signaling of ephrin‐B2 in migration of microglia
Sign Up to like & getrecommendations! Published in 2017 at "Glia"
DOI: 10.1002/glia.23147
Abstract: The Eph‐ephrin system plays pivotal roles in cell adhesion and migration. The receptor‐like functions of the ephrin ligands allow the regulation of intracellular processes via reverse signaling. γ‐Secretase mediated processing of ephrin‐B has previously been… read more here.
Keywords: intramembranous processing; secretase regulates; migration; processing secretase ... See more keywords
How CD40L reverse signaling regulates axon and dendrite growth
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DOI: 10.1007/s00018-020-03563-2
Abstract: CD40-activated CD40L reverse signaling is a major physiological regulator of axon and dendrite growth from developing hippocampal pyramidal neurons. Here we have studied how CD40L-mediated reverse signaling promotes the growth of these processes. Cultures of… read more here.
Keywords: cd40l reverse; dendrite growth; growth; axon dendrite ... See more keywords
Molecular mechanisms of FasL-mediated 'reverse-signaling'.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular immunology"
DOI: 10.1016/j.molimm.2020.08.010
Abstract: Effector lymphocytes, including NK and T cells, express FasL. Expression of Fas, the receptor for FasL in tumor cells, renders them susceptible to NK and T cell-mediated killing. The functional relevance of FasL in initiating… read more here.
Keywords: mediated reverse; signaling molecular; fasl mediated; molecular mechanisms ... See more keywords
Glycolipid iGb3 feedback amplifies innate immune responses via CD1d reverse signaling
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DOI: 10.1038/s41422-018-0122-7
Abstract: The cross-talk between cellular lipid metabolism and the innate immune responses remains obscure. In addition to presenting lipid antigens to Natural Killer T-cells (NKT cells), the Cluster of Differentiation 1D Glycoprotein (CD1d) might mediate reverse… read more here.
Keywords: immune responses; reverse; cd1d reverse; innate immune ... See more keywords
P038 In vivo demonstration of tmTNF reverse signaling: significance in the therapeutic response to anti-TNF agents during murine arthritis
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-ewrr2019.30
Abstract: Career situation of first and presenting author Post-doctoral fellow. Introduction Anti-TNF agents are widely used in rheumatoid arthritis (RA). Their effect on inflammation results from the neutralization of soluble TNF (sTNF), but also supposedly from… read more here.
Keywords: arthritis; anti tnf; reverse signaling;
The Notch Pathway Promotes Osteosarcoma Progression through Activation of Ephrin Reverse Signaling
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-19-0493
Abstract: Despite significant advancements in the diagnosis and treatment of osteosarcoma, the molecular mechanisms underpinning disease progression remain unclear. This work presents strong clinical and experimental evidence demonstrating that Notch signaling contributes to osteosarcoma progression. First,… read more here.
Keywords: reverse signaling; notch; progression; ephrin reverse ... See more keywords
CD70 reverse signaling enhances NK cell function and immunosurveillance in CD27-expressing B-cell malignancies.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2016-12-756585
Abstract: The interaction of the tumor necrosis factor receptor (TNFR) CD27 with its ligand CD70 is an emerging target to treat cancer. CD27 signaling provides costimulatory signals to cytotoxic T cells but also increases the frequency… read more here.
Keywords: cd27; cd70 reverse; function; cell ... See more keywords
Reverse Signaling of Tumor Necrosis Factor Superfamily Proteins in Macrophages and Microglia: Superfamily Portrait in the Neuroimmune Interface
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.00262
Abstract: The tumor necrosis factor (TNF) superfamily (TNFSF) is a protein superfamily of type II transmembrane proteins commonly containing the TNF homology domain. The superfamily contains more than 20 protein members, which can be released from… read more here.
Keywords: macrophages microglia; tumor necrosis; neuroimmune interface; necrosis factor ... See more keywords
The Chemokine Receptor CXCR6 Evokes Reverse Signaling via the Transmembrane Chemokine CXCL16
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms18071468
Abstract: Reverse signaling is a signaling mechanism where transmembrane or membrane-bound ligands transduce signals and exert biological effects upon binding of their specific receptors, enabling a bidirectional signaling between ligand and receptor-expressing cells. In this study,… read more here.
Keywords: transmembrane; cxcr6; cxcl16; receptor ... See more keywords