Garcinol from Garcinia indica inhibits HIV‐1 reverse transcriptase‐associated ribonuclease H
Sign Up to like & getrecommendations! Published in 2021 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202100123
Abstract: The bioactive components of Garcinia indica, garcinol (camboginol), and isogarcinol (cambogin), are suitable drug candidates for the treatment of various human diseases. HIV‐1‐RNase H assay was used to study the RNase H inhibition by garcinol… read more here.
Keywords: garcinol; garcinia indica; reverse transcriptase; hiv reverse ... See more keywords
Approaches to repurposing reverse transcriptase antivirals in cancer
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DOI: 10.1002/bcp.70113
Abstract: This review highlights the role of reverse transcriptase (RT) inhibition in cellular regulation associated with non‐terminal repeat retrotransposons and endogenous retroviruses. Based on their pleiotropic characteristics, RT inhibitors (RTIs) are discussed as potential anticancer agents.… read more here.
Keywords: cytotoxicity cancer; cell; transcriptase; reverse transcriptase ... See more keywords
A radiomics‐based nomogram may be useful for predicting telomerase reverse transcriptase promoter mutation status in adult glioblastoma
Sign Up to like & getrecommendations! Published in 2024 at "Brain and Behavior"
DOI: 10.1002/brb3.3528
Abstract: As a crucial diagnostic and prognostic biomarker, telomerase reverse transcriptase (TERT) promoter mutation holds immense significance for personalized treatment of patients with glioblastoma (GBM). In this study, we developed a radiomics nomogram to determine the… read more here.
Keywords: telomerase reverse; promoter; mutation status; reverse transcriptase ... See more keywords
Fluoride Pharmacokinetics in Urine and Plasma Following Multiple Doses of MK-8507, an Investigational, Oral, Once-Weekly Non-Nucleoside Reverse Transcriptase Inhibitor.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of clinical pharmacology"
DOI: 10.1002/jcph.1957
Abstract: MK-8507 is an investigational human immunodeficiency virus-1 (HIV-1) non-nucleoside reverse transcriptase inhibitor being developed for the treatment of HIV-1 infection. MK-8507 contains two trifluoromethyl groups that may result in fluoride release through metabolism, but the… read more here.
Keywords: non; nucleoside reverse; 8507 investigational; non nucleoside ... See more keywords
The presence of resistance‐associated mutations in reverse transcriptase gene is associated with cerebrospinal fluid HIV‐1 escape: A multicentric retrospective analysis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28704
Abstract: Higher risk of cerebrospinal fluid escape (CVE) has been associated with the use of specific antiretroviral (ARV) classes, such as protease inhibitors. We assessed whether archived resistance‐associated mutations (RAMs) can mediate this relationship by identifying… read more here.
Keywords: associated mutations; reverse transcriptase; presence; cerebrospinal fluid ... See more keywords
Deciphering the enigmas of non‐nucleoside reverse transcriptase inhibitors (NNRTIs): A medicinal chemistry expedition towards combating HIV drug resistance
Sign Up to like & getrecommendations! Published in 2024 at "Medicinal Research Reviews"
DOI: 10.1002/med.22080
Abstract: The pivotal involvement of reverse transcriptase activity in the pathogenesis of the progressive HIV virus has stimulated gradual advancements in drug discovery initiatives spanning three decades. Consequently, nonnucleoside reverse transcriptase inhibitors (NNRTIs) have emerged as… read more here.
Keywords: transcriptase inhibitors; chemistry; drug; reverse transcriptase ... See more keywords
Relative domain orientation of the L289K HIV‐1 reverse transcriptase monomer
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DOI: 10.1002/pro.4307
Abstract: HIV‐1 reverse transcriptase (RT) is a heterodimer comprised p66 and p51 subunits (p66/p51). Several single amino acid substitutions in RT, including L289K, decrease p66/p51 dimer affinity, and reduce enzymatic functioning. Here, small‐angle X‐ray scattering (SAXS)… read more here.
Keywords: reverse transcriptase; hiv reverse; domain; p66 p51 ... See more keywords
Biochemical properties of bacterial reverse transcriptase-related (rvt) gene products: multimerization, protein priming, and nucleotide preference
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DOI: 10.1007/s00294-018-0844-6
Abstract: Cellular reverse transcriptase-related (rvt) genes represent a novel class of reverse transcriptases (RTs), which are only distantly related to RTs of retrotransposons and retroviruses, but, similarly to telomerase RTs, are immobilized in the genome as… read more here.
Keywords: protein; biochemical properties; reverse; reverse transcriptase ... See more keywords
Reverse transcriptase loop-mediated isothermal amplification and reverse transcriptase recombinase amplification assays for rapid and sensitive detection of cardamom vein clearing virus
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DOI: 10.1007/s13205-020-02238-w
Abstract: In the present study, two isothermal molecular assays viz . reverse transcriptase loop-mediated isothermal amplification (RT-LAMP) and reverse transcriptase recombinase amplification (RT-RPA) were developed to detect the cardamom vein clearing virus (CdVCV) infecting cardamom. Assays… read more here.
Keywords: cardamom; pcr; transcriptase; reverse transcriptase ... See more keywords
Fluorescence-based biochemical analysis of human hepatitis B virus reverse transcriptase activity.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2020.113642
Abstract: Although the unique mechanism by which hepatitis B virus (HBV) polymerase primes reverse transcription is now well-characterized, the subsequent elongation process remains poorly understood. Reverse transcriptase (RT)-RNase H sequences from polymerase amino acid 304 (the… read more here.
Keywords: virus; reverse transcriptase; activity; hepatitis virus ... See more keywords
Early dynamic changes of quasispecies in the reverse transcriptase region of hepatitis B virus in telbivudine treatment.
Sign Up to like & getrecommendations! Published in 2021 at "Antiviral research"
DOI: 10.1016/j.antiviral.2021.105178
Abstract: BACKGROUND Telbivudine (LdT) - a synthetic thymidine β-L-nucleoside analogue (NA) - is an effective inhibitor for hepatitis B virus (HBV) replication. The quasispecies spectra in the reverse transcriptase (RT) region of the HBV genome and… read more here.
Keywords: treatment; transcriptase region; dynamic changes; hepatitis virus ... See more keywords