An Update on "Reverse Vaccinology": The Pathway from Genomes and Epitope Predictions to Tailored, Recombinant Vaccines.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1892-9_4
Abstract: In this chapter, we review the computational approaches that have led to a new generation of vaccines in recent years. There are many alternative routes to develop vaccines based on the concept of reverse vaccinology.… read more here.
Keywords: vaccinology pathway; reverse vaccinology; reverse; pathway genomes ... See more keywords
Identification of novel vaccine candidate against Salmonella enterica serovar Typhi by reverse vaccinology method and evaluation of its immunization.
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DOI: 10.1016/j.ygeno.2020.06.022
Abstract: Salmonella enterica serovar Typhi (S. Typhi) is an essential enteric fever causing bacterium worldwide. Due to the emergence of multidrug-resistant strains, urgently attention is needed to prevent the global spread of them. Vaccination is an… read more here.
Keywords: typhi; enterica serovar; salmonella enterica; serovar typhi ... See more keywords
Identification of Cross-Protective Potential Antigens against Pathogenic Brucella spp. through Combining Pan-Genome Analysis with Reverse Vaccinology
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Immunology Research"
DOI: 10.1155/2018/1474517
Abstract: Brucellosis is a zoonotic infectious disease caused by bacteria of the genus Brucella. Brucella melitensis, Brucella abortus, and Brucella suis are the most pathogenic species of this genus causing the majority of human and domestic… read more here.
Keywords: analysis; reverse vaccinology; brucella; potential antigens ... See more keywords
Reverse vaccinology approach to identify novel and immunogenic targets against Porphyromonas gingivalis: An in silico study
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DOI: 10.1371/journal.pone.0273770
Abstract: Porphyromonas gingivalis is a primary causative agent of chronic periodontitis. Moreover, it leads to several systemic diseases, including rheumatoid arthritis, cardiovascular, neurodegenerative, and Alzheimer’s diseases. It seems that the development of a vaccine against this… read more here.
Keywords: reverse vaccinology; immunogenic targets; identify novel; novel immunogenic ... See more keywords
Bacterial Vaccine Antigen Discovery in the Reverse Vaccinology 2.0 Era: Progress and Challenges
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.02315
Abstract: The ongoing, and very serious, threat from antimicrobial resistance necessitates the development and use of preventative measures, predominantly vaccination. Polysaccharide-based vaccines have provided a degree of success in limiting morbidity from disseminated bacterial infections, including… read more here.
Keywords: discovery; reverse vaccinology; bacterial vaccine; reverse ... See more keywords
Comparison of Open-Source Reverse Vaccinology Programs for Bacterial Vaccine Antigen Discovery
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.00113
Abstract: Reverse Vaccinology (RV) is a widely used approach to identify potential vaccine candidates (PVCs) by screening the proteome of a pathogen through computational analyses. Since its first application in Group B meningococcus (MenB) vaccine in… read more here.
Keywords: vaccine; open source; reverse vaccinology; comparison open ... See more keywords
Design of a multi-epitope vaccine against six Nocardia species based on reverse vaccinology combined with immunoinformatics
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DOI: 10.3389/fimmu.2023.1100188
Abstract: Background Nocardia genus, a complex group of species classified to be aerobic actinomycete, can lead to severe concurrent infection as well as disseminated infection, typically in immunocompromised patients. With the expansion of the susceptible population,… read more here.
Keywords: epitope vaccine; reverse vaccinology; vaccinology combined; multi epitope ... See more keywords
Genome-wide scan for potential CD4+ T-cell vaccine candidates in Candida auris by exploiting reverse vaccinology and evolutionary information
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.1008527
Abstract: Candida auris is a globally emerging fungal pathogen responsible for causing nosocomial outbreaks in healthcare associated settings. It is known to cause infection in all age groups and exhibits multi-drug resistance with high potential for… read more here.
Keywords: cell; reverse vaccinology; candida auris; vaccine candidates ... See more keywords
A Novel Pan-Genome Reverse Vaccinology Approach Employing a Negative-Selection Strategy for Screening Surface-Exposed Antigens against leptospirosis
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2017.00396
Abstract: Reverse vaccinology (RV) has been widely used for screening of surface-exposed proteins (PSEs) of important pathogens, including outer membrane proteins (OMPs), and extracellular proteins (ECPs) as potential vaccine candidates. In this study, we applied a… read more here.
Keywords: surface exposed; pan genome; strategy; screening surface ... See more keywords
Towards Reverse Vaccinology for Bovine TB: High Throughput Expression of Full Length Recombinant Mycobacterium bovis Proteins
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.889667
Abstract: Bovine tuberculosis caused by Mycobacterium bovis, is a significant global pathogen causing economic loss in livestock and zoonotic TB in man. Several vaccine approaches are in development including reverse vaccinology which uses an unbiased approach… read more here.
Keywords: bovis; reverse vaccinology; mycobacterium bovis; expression ... See more keywords
A reverse vaccinology approach identifies putative vaccination targets in the zoonotic nematode Ascaris
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2022.1014198
Abstract: Ascariasis is the most prevalent helminthic disease affecting both humans and pigs and is caused by the roundworms Ascaris lumbricoides and Ascaris suum. While preventive chemotherapy continues to be the most common control method, recent… read more here.
Keywords: reverse vaccinology; vaccination targets; vaccinology approach;