Regio-reversed alkenyl-arylation of ynamides via 1,3-olefin shift.
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DOI: 10.1039/d5sc07853a
Abstract: A cationic Pd-catalysed multicomponent reaction enables the regio-reversed alkenyl–arylation of ynamides through a migratory difunctionalization strategy. A stereoselective 1,3-olefin shift of a keteniminium–alkenyl–Pd intermediate governs the carbopalladation pathway, generating a vinylic Pd species that subsequently… read more here.
Keywords: arylation ynamides; reversed alkenyl; alkenyl arylation; olefin shift ... See more keywords