Tepotinib reverses ABCB1-mediated multidrug resistance in cancer cells.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.05.015
Abstract: Overexpression of ABCB1 transporters plays a crucial role in mediating multidrug resistance (MDR). Therefore, it is important to inhibit ABCB1 activity in order to maintain an effective intracellular level of chemotherapeutic drugs. Tepotinib is a… read more here.
Keywords: tepotinib reverses; mediated mdr; reverses abcb1; multidrug resistance ... See more keywords
Antimicrobial Peptide Reverses ABCB1-Mediated Chemotherapeutic Drug Resistance
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.01208
Abstract: Multidrug resistance (MDR) of tumor cells to chemotherapeutic agents is the main reason for the failure of cancer chemotherapy. Overexpression of ABCB1 transporter that actively pumps various drugs out of the cells has been considered… read more here.
Keywords: drug resistance; reverses abcb1; resistance; antimicrobial peptide ... See more keywords