In vitro to in vivo extrapolation of the complex drug‐drug interaction of bupropion and its metabolites with CYP2D6; simultaneous reversible inhibition and CYP2D6 downregulation
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DOI: 10.1016/j.bcp.2016.11.007
Abstract: Graphical abstract Figure. No Caption available. Abstract Bupropion is a widely used antidepressant and smoking cessation aid and a strong inhibitor of CYP2D6 in vivo. Bupropion is administered as a racemic mixture of R‐ and… read more here.
Keywords: cyp2d6; drug; bupropion metabolites; reversible inhibition ... See more keywords
Reversible inhibition of trypsin activity with soybean flour in hide bating process for leather quality improvement
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DOI: 10.1016/j.indcrop.2020.113222
Abstract: Abstract Trypsin is used to remove non-collagenous proteins from cattle hide in leather processing but prone to damage hide surface and reduce leather quality due to its rapid protein hydrolysis action on the hide surface… read more here.
Keywords: reversible inhibition; hide; leather quality; trypsin ... See more keywords
Reversible inhibition in the formation of copolymers based on alkyl (meth)acrylates with vinyl butyl ethers under compensation of the active monomer depending on their nature when initiated by the triethylborane–oxygen system
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DOI: 10.1016/j.jorganchem.2020.121396
Abstract: Abstract Compensatory (or compensation) copolymerization of alkyl (meth)acrylates (AMA) with boiling vinyl butyl ether (VBE), initiated by the system of triethylborane (TEB)–oxygen, has been studied. The obtained data indicate a partial formation of copolymer macromolecules… read more here.
Keywords: system; alkyl meth; vinyl butyl; meth acrylates ... See more keywords
Controlled Selectivity through Reversible Inhibition of the Catalyst: Stereodivergent Semihydrogenation of Alkynes
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DOI: 10.1021/jacs.2c04233
Abstract: Catalytic semihydrogenation of internal alkynes using H2 is an attractive atom-economical route to various alkenes, and its stereocontrol has received widespread attention, both in homogeneous and heterogeneous catalyses. Herein, a novel strategy is introduced, whereby… read more here.
Keywords: thiol; catalyst; selectivity; reversible inhibition ... See more keywords
Studies on biochemical, oxidative and genotoxicity alterations following vas blockage with reversible inhibition of sperm under guidance and reversal in rats
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DOI: 10.4103/ijp.ijp_557_20
Abstract: CONTEXT: Vas obstruction with reversible inhibition of sperm under guidance (RISUG) for contraception and its reversal, may cause oxidative stress or inimical effects on male reproductive functions. OBJECTIVE: To evaluate the biochemical and genotoxicity at… read more here.
Keywords: genotoxicity; sperm guidance; reversible inhibition; reversal ... See more keywords