Abstract 1652: A novel reversible inhibitor of XPO1 with potent efficacy in multiple preclinical mouse models
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DOI: 10.1158/1538-7445.am2023-1652
Abstract: Exportin 1 (XPO1/CRM1) is a key nuclear transport receptor (karyopherin) responsible for the export of different cargo proteins out of the cell’s nucleus into the cytoplasm. Its correct function is essential for cellular homeostasis, however… read more here.
Keywords: function; xpo1; inhibitor; efficacy ... See more keywords