Pharmacologically reversible, loss of function mutations in the TM2 and TM4 inner pore helices of TREK-1 K2P channels
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DOI: 10.1038/s41598-019-48855-1
Abstract: A better understanding of the gating of TREK two pore domain potassium (K2P) channels and their activation by compounds such as the negatively charged activator, flufenamic acid (FFA) is critical in the search for more… read more here.
Keywords: function mutations; reversible loss; k2p channels; pharmacologically reversible ... See more keywords