KRAS is vulnerable to reversible switch-II pocket engagement in cells
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DOI: 10.1038/s41589-022-00985-w
Abstract: Current small-molecule inhibitors of KRAS(G12C) bind irreversibly in the switch-II pocket (SII-P), exploiting the strong nucleophilicity of the acquired cysteine as well as the preponderance of the GDP-bound form of this mutant. Nevertheless, many oncogenic… read more here.
Keywords: spectroscopy; switch pocket; kras vulnerable; reversible switch ... See more keywords