No Protective Effect of Constitutive Activation of AMPK in Endothelial Cells on Vascular Function in Aged Obese Mice but Augmented α1-Adrenergic Contractions in Renal Arteries Reversible by Weight Loss
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DOI: 10.1159/000489959
Abstract: Background: Aging, obesity, and diabetes favor vascular dysfunction. Endothelial activation of adenosine monophosphate-activated protein kinase (AMPK) has protective effects in diabetes. Methods: Mice with constitutive endothelial activation of AMPK (CA-AMPK) were given a high fat… read more here.
Keywords: activation ampk; weight loss; renal arteries; activation ... See more keywords