Reversine exhibits antineoplastic activity in JAK2V617F-positive myeloproliferative neoplasms
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DOI: 10.1038/s41598-019-46163-2
Abstract: JAK2/STAT signaling participates in the Ph-negative myeloproliferative neoplasms (MPN) pathophysiology and has been targeted by ruxolitinib, a JAK1/2 inhibitor. In the present study, the impact of ruxolitinib treatment on cytoskeleton-related genes expression was explored. In… read more here.
Keywords: jak2v617f; set2 cells; reversine; expression ... See more keywords
In Vitro Characterization of Reversine-Treated Gingival Fibroblasts and Their Safety Evaluation after In Vivo Transplantation
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DOI: 10.3390/pharmaceutics16020207
Abstract: Reversine is a purine derivative that has been investigated with regard to its biological effects, such as its anticancer properties and, mostly, its ability to induce the dedifferentiation of adult cells, increasing their plasticity. The… read more here.
Keywords: gingival fibroblasts; stem; cell; reversine ... See more keywords
Reversine, a selective MPS1 inhibitor, induced autophagic cell death via diminished glucose uptake and ATP production in cholangiocarcinoma cells
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DOI: 10.7717/peerj.10637
Abstract: Reversine is a selective inhibitor of mitotic kinase monopolar spindle 1 (MPS1) and has been reported as an anticancer agent in various cancers. The effects of reversine on bile duct cancer, cholangiocarcinoma (CCA), a lethal… read more here.
Keywords: reversine selective; reversine; induced autophagic; cell death ... See more keywords