Shocking HIV-1 with immunomodulatory latency reversing agents.
Sign Up to like & getrecommendations! Published in 2021 at "Seminars in immunology"
DOI: 10.1016/j.smim.2021.101478
Abstract: The "shock-and-kill" strategy is one of the most explored HIV-1 cure approaches to eliminate latent virus. This strategy is based on HIV-1 reactivation using latency reversing agents (LRAs) to reactivate latent proviruses (the "shock" phase)… read more here.
Keywords: latency; hiv immunomodulatory; hiv; shocking hiv ... See more keywords
Epigenetic Regulation of HIV-1 Sense and Antisense Transcription in Response to Latency-Reversing Agents
Sign Up to like & getrecommendations! Published in 2023 at "Non-Coding RNA"
DOI: 10.3390/ncrna9010005
Abstract: Nucleosomes positioned on the HIV-1 5′ long terminal repeat (LTR) regulate sense transcription as well as the establishment and maintenance of latency. A negative-sense promoter (NSP) in the 3′ LTR expresses antisense transcripts with coding… read more here.
Keywords: transcription; latency reversing; sense antisense; reversing agents ... See more keywords